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APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p

Author

Listed:
  • Kun Wang

    (Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Cui-Yun Liu

    (State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences)

  • Lu-Yu Zhou

    (Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Jian-Xun Wang

    (Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Man Wang

    (Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Bing Zhao

    (Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Wen-Ke Zhao

    (Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Shi-Jun Xu

    (Anzen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University)

  • Li-Hua Fan

    (State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences)

  • Xiao-Jie Zhang

    (State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences)

  • Chang Feng

    (State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences)

  • Chao-Qun Wang

    (Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Yan-Fang Zhao

    (Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Pei-Feng Li

    (Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University)

Abstract

The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autophagy in the heart is unclear. Here we report that a long noncoding RNA, named autophagy promoting factor (APF), can regulate autophagic cell death by targeting miR-188-3p and ATG7. The results show that miR-188-3p suppresses autophagy and myocardial infarction by targeting ATG7. Further, we find that APF lncRNA regulates miR-188-3p, and thus affects ATG7 expression, autophagic cell death and myocardial infarction. Our present study reveals a novel regulating model of autophagic programme, which comprises APF, miR-188-3p and ATG7 in the heart. Modulation of their levels may serve as potential targets and diagnostic tools for novel therapeutic strategies of myocardial infarction and heart failure.

Suggested Citation

  • Kun Wang & Cui-Yun Liu & Lu-Yu Zhou & Jian-Xun Wang & Man Wang & Bing Zhao & Wen-Ke Zhao & Shi-Jun Xu & Li-Hua Fan & Xiao-Jie Zhang & Chang Feng & Chao-Qun Wang & Yan-Fang Zhao & Pei-Feng Li, 2015. "APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7779
    DOI: 10.1038/ncomms7779
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