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Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis

Author

Listed:
  • Lucy A. Weinert

    (University of Cambridge)

  • Roy R. Chaudhuri

    (University of Sheffield)

  • Jinhong Wang

    (University of Cambridge)

  • Sarah E. Peters

    (University of Cambridge)

  • Jukka Corander

    (University of Helsinki)

  • Thibaut Jombart

    (MRC Centre for Outbreak Analysis and Modelling, Faculty of Medicine)

  • Abiyad Baig

    (University of Cambridge)

  • Kate J. Howell

    (University of Cambridge)

  • Minna Vehkala

    (University of Helsinki)

  • Niko Välimäki

    (University of Helsinki)

  • David Harris

    (The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Tran Thi Bich Chieu

    (Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases)

  • Nguyen Van Vinh Chau

    (Hospital for Tropical Diseases)

  • James Campbell

    (Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases
    Centre for Tropical Medicine, University of Oxford)

  • Constance Schultsz

    (Academic Medical Centre, University of Amsterdam)

  • Julian Parkhill

    (The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Stephen D. Bentley

    (The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
    Present Address: Department of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 0SP, UK (S.D.B.);)

  • Paul R. Langford

    (Section of Paediatrics, Faculty of Medicine, Imperial College London)

  • Andrew N. Rycroft

    (The Royal Veterinary College, Hawkshead Campus)

  • Brendan W. Wren

    (Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine)

  • Jeremy Farrar

    (Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases
    Centre for Tropical Medicine, University of Oxford)

  • Stephen Baker

    (Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases
    Centre for Tropical Medicine, University of Oxford
    Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine)

  • Ngo Thi Hoa

    (Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases
    Centre for Tropical Medicine, University of Oxford)

  • Matthew T.G. Holden

    (The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Alexander W. Tucker

    (University of Cambridge)

  • Duncan J. Maskell

    (University of Cambridge)

Abstract

Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates with detailed clinical phenotypes from pigs and humans from the United Kingdom and Vietnam. Here, we show that isolates associated with disease contain substantially fewer genes than non-clinical isolates, but are more likely to encode virulence factors. Human disease isolates are limited to a single-virulent population, originating in the 1920, s when pig production was intensified, but no consistent genomic differences between pig and human isolates are observed. There is little geographical clustering of different S. suis subpopulations, and the bacterium undergoes high rates of recombination, implying that an increase in virulence anywhere in the world could have a global impact over a short timescale.

Suggested Citation

  • Lucy A. Weinert & Roy R. Chaudhuri & Jinhong Wang & Sarah E. Peters & Jukka Corander & Thibaut Jombart & Abiyad Baig & Kate J. Howell & Minna Vehkala & Niko Välimäki & David Harris & Tran Thi Bich Chi, 2015. "Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7740
    DOI: 10.1038/ncomms7740
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