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Human monoclonal antibodies targeting the haemagglutinin glycoprotein can neutralize H7N9 influenza virus

Author

Listed:
  • Zhe Chen

    (MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jianmin Wang

    (MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Linlin Bao

    (Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical Collage (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health)

  • Li Guo

    (MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Weijia Zhang

    (MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Ying Xue

    (MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Hongli Zhou

    (MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yan Xiao

    (MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jianwei Wang

    (MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Fan Wu

    (Shanghai Municipal Center for Disease Control and Prevention)

  • Ying Deng

    (Beijing Municipal Center for Disease Control and Prevention)

  • Chuan Qin

    (Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical Collage (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health)

  • Qi Jin

    (MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College)

Abstract

The recently identified avian-originated influenza H7N9 virus causes severe pulmonary disease and may lead to death in humans. Currently, treatment options for the prevention and control of fatal H7N9 infections in humans remain limited. Here we characterize two human monoclonal antibodies (HuMAbs), HNIgGA6 and HNIgGB5, by screening a Fab antibody phage library derived from patients who recovered from H7N9 infection. Both antibodies exhibit high neutralizing activity against H7N9 virus in cells. Two amino acids in the receptor-binding site, 186V and 226L, are crucial for the binding of these two HuMAbs to viral haemagglutinin antigens. Prophylaxis with HNIgGA6 and HNIgGB5 confers significant immunity against H7N9 virus in a mouse model and significantly reduces the pulmonary virus titre. When administered post infection, therapeutic doses of the HuMAbs also provide robust protection against lethality. These antibodies might represent a potential alternative or adjunct to H7N9 pandemic interventions.

Suggested Citation

  • Zhe Chen & Jianmin Wang & Linlin Bao & Li Guo & Weijia Zhang & Ying Xue & Hongli Zhou & Yan Xiao & Jianwei Wang & Fan Wu & Ying Deng & Chuan Qin & Qi Jin, 2015. "Human monoclonal antibodies targeting the haemagglutinin glycoprotein can neutralize H7N9 influenza virus," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7714
    DOI: 10.1038/ncomms7714
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    Cited by:

    1. Manxue Jia & Hanjun Zhao & Nicholas C. Morano & Hong Lu & Yin-Ming Lui & Haijuan Du & Jordan E. Becker & Kwok-Yung Yuen & David D. Ho & Peter D. Kwong & Lawrence Shapiro & Kelvin Kai-Wang To & Xueling, 2024. "Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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