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Global migration of influenza A viruses in swine

Author

Listed:
  • Martha I. Nelson

    (Fogarty International Center, National Institutes of Health)

  • Cécile Viboud

    (Fogarty International Center, National Institutes of Health)

  • Amy L. Vincent

    (Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-ARS)

  • Marie R. Culhane

    (University of Minnesota Veterinary Diagnostic Laboratory)

  • Susan E. Detmer

    (Western College of Veterinary Medicine, University of Saskatchewan)

  • David E. Wentworth

    (J Craig Venter Institute
    Present address: Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA)

  • Andrew Rambaut

    (Fogarty International Center, National Institutes of Health
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories
    Centre for Immunology, Infection and Evolution, University of Edinburgh, Ashworth Laboratories)

  • Marc A. Suchard

    (Biostatistics, and Human Genetics, University of California)

  • Edward C. Holmes

    (Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, University of Sydney)

  • Philippe Lemey

    (Rega Institute, KU Leuven—University of Leuven)

Abstract

The complex and unresolved evolutionary origins of the 2009 H1N1 influenza pandemic exposed major gaps in our knowledge of the global spatial ecology and evolution of influenza A viruses in swine (swIAVs). Here we undertake an expansive phylogenetic analysis of swIAV sequence data and demonstrate that the global live swine trade strongly predicts the spatial dissemination of swIAVs, with Europe and North America acting as sources of viruses in Asian countries. In contrast, China has the world’s largest swine population but is not a major exporter of live swine, and is not an important source of swIAVs in neighbouring Asian countries or globally. A meta-population simulation model incorporating trade data predicts that the global ecology of swIAVs is more complex than previously thought, and the United States and China’s large swine populations are unlikely to be representative of swIAV diversity in their respective geographic regions, requiring independent surveillance efforts throughout Latin America and Asia.

Suggested Citation

  • Martha I. Nelson & Cécile Viboud & Amy L. Vincent & Marie R. Culhane & Susan E. Detmer & David E. Wentworth & Andrew Rambaut & Marc A. Suchard & Edward C. Holmes & Philippe Lemey, 2015. "Global migration of influenza A viruses in swine," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7696
    DOI: 10.1038/ncomms7696
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    Cited by:

    1. Sheila Keay & Zvonimir Poljak & Mackenzie Klapwyk & Annette O’Connor & Robert M Friendship & Terri L O’Sullivan & Jan M Sargeant, 2020. "Influenza A virus vaccine research conducted in swine from 1990 to May 2018: A scoping review," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-27, July.
    2. Romain Espinosa & Damian Tago & Nicolas Treich, 2020. "Infectious Diseases and Meat Production," Environmental & Resource Economics, Springer;European Association of Environmental and Resource Economists, vol. 76(4), pages 1019-1044, August.

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