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Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances

Author

Listed:
  • Jan Mani

    (University of Bern)

  • Silvia Desy

    (University of Bern)

  • Moritz Niemann

    (University of Bern)

  • Astrid Chanfon

    (University of Bern)

  • Silke Oeljeklaus

    (Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg)

  • Mascha Pusnik

    (University of Bern
    Present address: HES-SO Valais, Institute of Life Technologies, CH-1950 Sion, Switzerland)

  • Oliver Schmidt

    (Institut für Biochemie und Molekularbiologie, ZBMZ and BIOSS Centre for Biological Signalling Studies, Universität Freiburg
    Present address: Innsbruck Medical University, Innsbruck Biocenter, Division of Cell Biology, Innrain 80, A-6020 Innsbruck, Austria)

  • Carolin Gerbeth

    (Institut für Biochemie und Molekularbiologie, ZBMZ and BIOSS Centre for Biological Signalling Studies, Universität Freiburg)

  • Chris Meisinger

    (Institut für Biochemie und Molekularbiologie, ZBMZ and BIOSS Centre for Biological Signalling Studies, Universität Freiburg)

  • Bettina Warscheid

    (Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg)

  • André Schneider

    (University of Bern)

Abstract

Mitochondrial protein import is essential for all eukaryotes and mediated by hetero-oligomeric protein translocases thought to be conserved within all eukaryotes. We have identified and analysed the function and architecture of the non-conventional outer membrane (OM) protein translocase in the early diverging eukaryote Trypanosoma brucei. It consists of six subunits that show no obvious homology to translocase components of other species. Two subunits are import receptors that have a unique topology and unique protein domains and thus evolved independently of the prototype receptors Tom20 and Tom70. Our study suggests that protein import receptors were recruited to the core of the OM translocase after the divergence of the major eukaryotic supergroups. Moreover, it links the evolutionary history of mitochondrial protein import receptors to the origin of the eukaryotic supergroups.

Suggested Citation

  • Jan Mani & Silvia Desy & Moritz Niemann & Astrid Chanfon & Silke Oeljeklaus & Mascha Pusnik & Oliver Schmidt & Carolin Gerbeth & Chris Meisinger & Bettina Warscheid & André Schneider, 2015. "Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7646
    DOI: 10.1038/ncomms7646
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    Cited by:

    1. Abhijith Makki & Petr Rada & Vojtěch Žárský & Sami Kereïche & Lubomír Kováčik & Marian Novotný & Tobias Jores & Doron Rapaport & Jan Tachezy, 2019. "Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis," PLOS Biology, Public Library of Science, vol. 17(1), pages 1-32, January.
    2. Caroline E. Dewar & Silke Oeljeklaus & Jan Mani & Wignand W. D. Mühlhäuser & Corinne Känel & Johannes Zimmermann & Torsten Ochsenreiter & Bettina Warscheid & André Schneider, 2022. "Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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