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Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice

Author

Listed:
  • Stefano Garofalo

    (Istituto Pasteur-Fondazione Cenci Bolognetti Sapienza University)

  • Giuseppina D’Alessandro

    (Istituto Pasteur-Fondazione Cenci Bolognetti Sapienza University)

  • Giuseppina Chece

    (Istituto Pasteur-Fondazione Cenci Bolognetti Sapienza University)

  • Frederic Brau

    (Université Nice-Sophia Antipolis, IPMC CNRS-UMR)

  • Laura Maggi

    (Istituto Pasteur-Fondazione Cenci Bolognetti Sapienza University)

  • Alessandro Rosa

    (Sapienza University)

  • Alessandra Porzia

    (Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University)

  • Fabrizio Mainiero

    (Sapienza University)

  • Vincenzo Esposito

    (IRCCS Neuromed
    Sapienza University)

  • Clotilde Lauro

    (Istituto Pasteur-Fondazione Cenci Bolognetti Sapienza University)

  • Giorgia Benigni

    (Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University)

  • Giovanni Bernardini

    (Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University)

  • Angela Santoni

    (Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University
    IRCCS Neuromed)

  • Cristina Limatola

    (Istituto Pasteur-Fondazione Cenci Bolognetti Sapienza University
    IRCCS Neuromed)

Abstract

Mice exposed to standard (SE) or enriched environment (EE) were transplanted with murine or human glioma cells and differences in tumour development were evaluated. We report that EE exposure affects: (i) tumour size, increasing mice survival; (ii) glioma establishment, proliferation and invasion; (iii) microglia/macrophage (M/Mφ) activation; (iv) natural killer (NK) cell infiltration and activation; and (v) cerebral levels of IL-15 and BDNF. Direct infusion of IL-15 or BDNF in the brain of mice transplanted with glioma significantly reduces tumour growth. We demonstrate that brain infusion of IL-15 increases the frequency of NK cell infiltrating the tumour and that NK cell depletion reduces the efficacy of EE and IL-15 on tumour size and of EE on mice survival. BDNF infusion reduces M/Mφ infiltration and CD68 immunoreactivity in tumour mass and reduces glioma migration inhibiting the small G protein RhoA through the truncated TrkB.T1 receptor. These results suggest alternative approaches for glioma treatment.

Suggested Citation

  • Stefano Garofalo & Giuseppina D’Alessandro & Giuseppina Chece & Frederic Brau & Laura Maggi & Alessandro Rosa & Alessandra Porzia & Fabrizio Mainiero & Vincenzo Esposito & Clotilde Lauro & Giorgia Ben, 2015. "Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice," Nature Communications, Nature, vol. 6(1), pages 1-13, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7623
    DOI: 10.1038/ncomms7623
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    Cited by:

    1. Stefano Garofalo & Germana Cocozza & Alessandro Mormino & Giovanni Bernardini & Eleonora Russo & Donald Ielpo & Diego Andolina & Rossella Ventura & Katiuscia Martinello & Massimiliano Renzi & Sergio F, 2023. "Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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