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Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity

Author

Listed:
  • Stefan Harmsen

    (Memorial Sloan Kettering Cancer Center)

  • Matthew A. Bedics

    (University at Buffalo, The State University of New York)

  • Matthew A. Wall

    (Memorial Sloan Kettering Cancer Center
    Hunter College of the City University of New York)

  • Ruimin Huang

    (Memorial Sloan Kettering Cancer Center)

  • Michael R. Detty

    (University at Buffalo, The State University of New York)

  • Moritz F. Kircher

    (Memorial Sloan Kettering Cancer Center
    Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical College)

Abstract

High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection.

Suggested Citation

  • Stefan Harmsen & Matthew A. Bedics & Matthew A. Wall & Ruimin Huang & Michael R. Detty & Moritz F. Kircher, 2015. "Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7570
    DOI: 10.1038/ncomms7570
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    Cited by:

    1. Jacopo Cardellini & Caterina Dallari & Ilaria Santis & Lorenzo Riccio & Costanza Ceni & Amelia Morrone & Martino Calamai & Francesco Saverio Pavone & Caterina Credi & Costanza Montis & Debora Berti, 2024. "Hybrid lipid-AuNP clusters as highly efficient SERS substrates for biomedical applications," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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