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The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation

Author

Listed:
  • Bart Tummers

    (Leiden University Medical Center)

  • Renske Goedemans

    (Leiden University Medical Center)

  • Laetitia P. L. Pelascini

    (Leiden University Medical Center)

  • Ekaterina S. Jordanova

    (Center for Gynaecological Oncology)

  • Edith M. G. van Esch

    (Leiden University Medical Center)

  • Craig Meyers

    (The Pennsylvania State University College of Medicine)

  • Cornelis J. M. Melief

    (Leiden University Medical Center)

  • Judith M. Boer

    (Leiden University Medical Center
    Present addresses: Department of Pediatric Oncology, Erasmus MC—Sophia Children’s Hospital, Wytemaweg 80, 3015CN Rotterdam, The Netherlands; Netherlands Bioinformatics Center, Geert Grooteplein-Zuid 28, 6525GA Nijmegen, The Netherlands.)

  • Sjoerd H. van der Burg

    (Leiden University Medical Center)

Abstract

High-risk human papillomaviruses (hrHPVs) infect keratinocytes and successfully evade host immunity despite the fact that keratinocytes are well equipped to respond to innate and adaptive immune signals. Using non-infected and freshly established or persistent hrHPV-infected keratinocytes we show that hrHPV impairs the acetylation of NFκB/RelA K310 in keratinocytes. As a consequence, keratinocytes display a decreased pro-inflammatory cytokine production and immune cell attraction in response to stimuli of the innate or adaptive immune pathways. HPV accomplishes this by augmenting the expression of interferon-related developmental regulator 1 (IFRD1) in an EGFR-dependent manner. Restoration of NFκB/RelA acetylation by IFRD1 shRNA, cetuximab treatment or the HDAC1/3 inhibitor entinostat increases basal and induced cytokine expression. Similar observations are made in IFRD1-overexpressing HPV-induced cancer cells. Thus, our study reveals an EGFR–IFRD1-mediated viral immune evasion mechanism, which can also be exploited by cancer cells.

Suggested Citation

  • Bart Tummers & Renske Goedemans & Laetitia P. L. Pelascini & Ekaterina S. Jordanova & Edith M. G. van Esch & Craig Meyers & Cornelis J. M. Melief & Judith M. Boer & Sjoerd H. van der Burg, 2015. "The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7537
    DOI: 10.1038/ncomms7537
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    1. Julia Joung & Paul C. Kirchgatterer & Ankita Singh & Jang H. Cho & Suchita P. Nety & Rebecca C. Larson & Rhiannon K. Macrae & Rebecca Deasy & Yuen-Yi Tseng & Marcela V. Maus & Feng Zhang, 2022. "CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Alizee Lebeau & Diane Bruyere & Patrick Roncarati & Paul Peixoto & Eric Hervouet & Gael Cobraiville & Bernard Taminiau & Murielle Masson & Carmen Gallego & Gabriel Mazzucchelli & Nicolas Smargiasso & , 2022. "HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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