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Neutral particle mass spectrometry with nanomechanical systems

Author

Listed:
  • Eric Sage

    (Université Grenoble Alpes
    CEA, LETI, Minatec Campus)

  • Ariel Brenac

    (Université Grenoble Alpes, INAC-SP2M
    CEA, INAC- SP2M)

  • Thomas Alava

    (Université Grenoble Alpes
    CEA, LETI, Minatec Campus)

  • Robert Morel

    (Université Grenoble Alpes, INAC-SP2M
    CEA, INAC- SP2M)

  • Cécilia Dupré

    (Université Grenoble Alpes
    CEA, LETI, Minatec Campus)

  • Mehmet Selim Hanay

    (Applied Physics, and Bioengineering, Kavli Nanoscience Institute, California Institute of Technology
    Present address: Department of Mechanical Engineering and UNAM, Bilkent University, Ankara 06800, Turkey)

  • Michael L. Roukes

    (Applied Physics, and Bioengineering, Kavli Nanoscience Institute, California Institute of Technology)

  • Laurent Duraffourg

    (Université Grenoble Alpes
    CEA, LETI, Minatec Campus)

  • Christophe Masselon

    (Université Grenoble Alpes
    CEA, IRTSV, Biologie à Grande Echelle
    INSERM, U1038)

  • Sébastien Hentz

    (Université Grenoble Alpes
    CEA, LETI, Minatec Campus)

Abstract

Current approaches to mass spectrometry (MS) require ionization of the analytes of interest. For high-mass species, the resulting charge state distribution can be complex and difficult to interpret correctly. Here, using a setup comprising both conventional time-of-flight MS (TOF-MS) and nano-electromechanical systems-based MS (NEMS-MS) in situ, we show directly that NEMS-MS analysis is insensitive to charge state: the spectrum consists of a single peak whatever the species’ charge state, making it significantly clearer than existing MS analysis. In subsequent tests, all the charged particles are electrostatically removed from the beam, and unlike TOF-MS, NEMS-MS can still measure masses. This demonstrates the possibility to measure mass spectra for neutral particles. Thus, it is possible to envisage MS-based studies of analytes that are incompatible with current ionization techniques and the way is now open for the development of cutting-edge system architectures with unique analytical capability.

Suggested Citation

  • Eric Sage & Ariel Brenac & Thomas Alava & Robert Morel & Cécilia Dupré & Mehmet Selim Hanay & Michael L. Roukes & Laurent Duraffourg & Christophe Masselon & Sébastien Hentz, 2015. "Neutral particle mass spectrometry with nanomechanical systems," Nature Communications, Nature, vol. 6(1), pages 1-5, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7482
    DOI: 10.1038/ncomms7482
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    Cited by:

    1. John E. Sader & Alfredo Gomez & Adam P. Neumann & Alex Nunn & Michael L. Roukes, 2024. "Data-driven fingerprint nanoelectromechanical mass spectrometry," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Samantha Sbarra & Louis Waquier & Stephan Suffit & Aristide Lemaître & Ivan Favero, 2022. "Optomechanical measurement of single nanodroplet evaporation with millisecond time-resolution," Nature Communications, Nature, vol. 13(1), pages 1-7, December.

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