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Bacterial killing via a type IV secretion system

Author

Listed:
  • Diorge P. Souza

    (Instituto de Química, Universidade de São Paulo)

  • Gabriel U. Oka

    (Instituto de Química, Universidade de São Paulo)

  • Cristina E. Alvarez-Martinez

    (Instituto de Química, Universidade de São Paulo
    Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas)

  • Alexandre W. Bisson-Filho

    (Instituto de Química, Universidade de São Paulo)

  • German Dunger

    (Instituto de Química, Universidade de São Paulo)

  • Lise Hobeika

    (Instituto de Química, Universidade de São Paulo)

  • Nayara S. Cavalcante

    (Instituto de Física de São Carlos, Universidade de São Paulo)

  • Marcos C. Alegria

    (Instituto de Química, Universidade de São Paulo
    Present address: Cristália Produtos Químicos Farmacêuticos Ltda, Divisão de Biotecnologia, Rodovia Itapira-Lindóia km 14, Itapira, SP 13970-970, Brazil)

  • Leandro R.S. Barbosa

    (Instituto de Física, Universidade de São Paulo)

  • Roberto K. Salinas

    (Instituto de Química, Universidade de São Paulo)

  • Cristiane R. Guzzo

    (Instituto de Química, Universidade de São Paulo
    Instituto de Ciências Biomédicas, Universidade de São Paulo)

  • Chuck S. Farah

    (Instituto de Química, Universidade de São Paulo)

Abstract

Type IV secretion systems (T4SSs) are multiprotein complexes that transport effector proteins and protein–DNA complexes through bacterial membranes to the extracellular milieu or directly into the cytoplasm of other cells. Many bacteria of the family Xanthomonadaceae, which occupy diverse environmental niches, carry a T4SS with unknown function but with several characteristics that distinguishes it from other T4SSs. Here we show that the Xanthomonas citri T4SS provides these cells the capacity to kill other Gram-negative bacterial species in a contact-dependent manner. The secretion of one type IV bacterial effector protein is shown to require a conserved C-terminal domain and its bacteriolytic activity is neutralized by a cognate immunity protein whose 3D structure is similar to peptidoglycan hydrolase inhibitors. This is the first demonstration of the involvement of a T4SS in bacterial killing and points to this special class of T4SS as a mediator of both antagonistic and cooperative interbacterial interactions.

Suggested Citation

  • Diorge P. Souza & Gabriel U. Oka & Cristina E. Alvarez-Martinez & Alexandre W. Bisson-Filho & German Dunger & Lise Hobeika & Nayara S. Cavalcante & Marcos C. Alegria & Leandro R.S. Barbosa & Roberto K, 2015. "Bacterial killing via a type IV secretion system," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7453
    DOI: 10.1038/ncomms7453
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    Cited by:

    1. Kate MacKrill & Connor Silvester & James W. Pennebaker & Keith J. Petrie, 2021. "What makes an idea worth spreading? Language markers of popularity in TED talks by academics and other speakers," Journal of the Association for Information Science & Technology, Association for Information Science & Technology, vol. 72(8), pages 1028-1038, August.
    2. Matthieu Haudiquet & Julie Bris & Amandine Nucci & Rémy A. Bonnin & Pilar Domingo-Calap & Eduardo P. C. Rocha & Olaya Rendueles, 2024. "Capsules and their traits shape phage susceptibility and plasmid conjugation efficiency," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Himani Amin & Aravindan Ilangovan & Tiago R. D. Costa, 2021. "Architecture of the outer-membrane core complex from a conjugative type IV secretion system," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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