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Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

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  • Jyoti Parkash

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114)
    Present address: Department of Biotechnology, School of Life Sciences, D.A.V. University Jalandhar, Punjab 144001, India)

  • Andrea Messina

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

  • Fanny Langlet

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

  • Irene Cimino

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

  • Anne Loyens

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

  • Danièle Mazur

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

  • Sarah Gallet

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

  • Eglantine Balland

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

  • Samuel A. Malone

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

  • François Pralong

    (Service of Endocrinology, Diabetology and Metabolism, Faculty of Biology and Medicine, University Hospital)

  • Gabriella Cagnoni

    (Candiolo Cancer Institute—FPO, IRCCS
    University of Torino)

  • Roberta Schellino

    (University of Torino)

  • Silvia De Marchis

    (University of Torino)

  • Massimiliano Mazzone

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, KU Leuven)

  • R. Jeroen Pasterkamp

    (Brain Center Rudolf Magnus, University Medical Center Utrecht)

  • Luca Tamagnone

    (Candiolo Cancer Institute—FPO, IRCCS
    University of Torino)

  • Vincent Prevot

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

  • Paolo Giacobini

    (Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre
    University of Lille, School of Medicine and Institut de Medecine Predictive et de Recherche Therapeutique (IMPRT-IFR114))

Abstract

Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic–pituitary–gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle.

Suggested Citation

  • Jyoti Parkash & Andrea Messina & Fanny Langlet & Irene Cimino & Anne Loyens & Danièle Mazur & Sarah Gallet & Eglantine Balland & Samuel A. Malone & François Pralong & Gabriella Cagnoni & Roberta Schel, 2015. "Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence," Nature Communications, Nature, vol. 6(1), pages 1-17, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7385
    DOI: 10.1038/ncomms7385
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    Cited by:

    1. Noemie Vilallongue & Julia Schaeffer & Anne-Marie Hesse & Céline Delpech & Béatrice Blot & Antoine Paccard & Elise Plissonnier & Blandine Excoffier & Yohann Couté & Stephane Belin & Homaira Nawabi, 2022. "Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Antonella Lettieri & Roberto Oleari & Marleen Hester Munkhof & Eljo Yvette Battum & Marieke Geerte Verhagen & Carlotta Tacconi & Marco Spreafico & Alyssa Julia Jennifer Paganoni & Roberta Azzarelli & , 2023. "SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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