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Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

Author

Listed:
  • Xiumei Hong

    (Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA)

  • Ke Hao

    (Icahn School of Medicine at Mount Sinai)

  • Christine Ladd-Acosta

    (Johns Hopkins University Bloomberg School of Public Health)

  • Kasper D. Hansen

    (Johns Hopkins University Bloomberg School of Public Health Baltimore
    McKusick-Nathans Insitute of Genetic Medicine, Johns Hopkins University School of Medicine)

  • Hui-Ju Tsai

    (Mary Ann and J. Milburn Smith Child Health Research Program, Northwestern University Feinberg School of Medicine and Stanley Manne Children’s Research Institute, Ann and Robert H. Lurie Children’s Hospital of Chicago
    Institute of Population Health Sciences, National Health Research Institutes
    China Medical University)

  • Xin Liu

    (Mary Ann and J. Milburn Smith Child Health Research Program, Northwestern University Feinberg School of Medicine and Stanley Manne Children’s Research Institute, Ann and Robert H. Lurie Children’s Hospital of Chicago
    Northwestern University Feinberg School of Medicine)

  • Xin Xu

    (Guangdong Provincial Institute of Nephrology, Southern Medical University)

  • Timothy A. Thornton

    (University of Washington)

  • Deanna Caruso

    (Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA)

  • Corinne A. Keet

    (Johns Hopkins University Bloomberg School of Public Health
    Johns Hopkins University School of Medicine)

  • Yifei Sun

    (Johns Hopkins University Bloomberg School of Public Health Baltimore)

  • Guoying Wang

    (Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA)

  • Wei Luo

    (Icahn School of Medicine at Mount Sinai
    College of Computer Science and Technology, Huaqiao University)

  • Rajesh Kumar

    (Ann and Robert H. Lurie Children’s Hospital of Chicago)

  • Ramsay Fuleihan

    (Ann and Robert H. Lurie Children’s Hospital of Chicago)

  • Anne Marie Singh

    (Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern Feinberg School of Medicine)

  • Jennifer S. Kim

    (Ann and Robert H. Lurie Children’s Hospital of Chicago
    NorthShore University HealthSystem)

  • Rachel E. Story

    (Ann and Robert H. Lurie Children’s Hospital of Chicago
    NorthShore University Health Systems, Pritzker School of Medicine, University of Chicago)

  • Ruchi S. Gupta

    (Mary Ann and J. Milburn Smith Child Health Research Program, Northwestern University Feinberg School of Medicine and Stanley Manne Children’s Research Institute, Ann and Robert H. Lurie Children’s Hospital of Chicago)

  • Peisong Gao

    (Johns Hopkins University School of Medicine)

  • Zhu Chen

    (Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA)

  • Sheila O. Walker

    (Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA)

  • Tami R. Bartell

    (Mary Ann and J. Milburn Smith Child Health Research Program, Northwestern University Feinberg School of Medicine and Stanley Manne Children’s Research Institute, Ann and Robert H. Lurie Children’s Hospital of Chicago)

  • Terri H. Beaty

    (Johns Hopkins University Bloomberg School of Public Health)

  • M. Daniele Fallin

    (Wendy Klag Center for Autism and Developmental Disabilities, Bloomberg School of Public Health, Johns Hopkins University)

  • Robert Schleimer

    (Northwestern University Feinberg School of Medicine)

  • Patrick G. Holt

    (Telethon Kids Institute, University of Western Australia
    Perth and Queensland Children’s Medical Research Institute, University of Queensland)

  • Kari Christine Nadeau

    (Immunology and Rheumatology, Stanford University School of Medicine)

  • Robert A. Wood

    (Johns Hopkins University School of Medicine)

  • Jacqueline A. Pongracic

    (Ann and Robert H. Lurie Children’s Hospital of Chicago)

  • Daniel E. Weeks

    (Graduate School of Public Health, University of Pittsburgh)

  • Xiaobin Wang

    (Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA
    Johns Hopkins University School of Medicine)

Abstract

Food allergy (FA) affects 2%–10% of US children and is a growing clinical and public health problem. Here we conduct the first genome-wide association study of well-defined FA, including specific subtypes (peanut, milk and egg) in 2,759 US participants (1,315 children and 1,444 parents) from the Chicago Food Allergy Study, and identify peanut allergy (PA)-specific loci in the HLA-DR and -DQ gene region at 6p21.32, tagged by rs7192 (P=5.5 × 10−8) and rs9275596 (P=6.8 × 10−10), in 2,197 participants of European ancestry. We replicate these associations in an independent sample of European ancestry. These associations are further supported by meta-analyses across the discovery and replication samples. Both single-nucleotide polymorphisms (SNPs) are associated with differential DNA methylation levels at multiple CpG sites (P

Suggested Citation

  • Xiumei Hong & Ke Hao & Christine Ladd-Acosta & Kasper D. Hansen & Hui-Ju Tsai & Xin Liu & Xin Xu & Timothy A. Thornton & Deanna Caruso & Corinne A. Keet & Yifei Sun & Guoying Wang & Wei Luo & Rajesh K, 2015. "Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7304
    DOI: 10.1038/ncomms7304
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    Cited by:

    1. Majid Pahlevan Kakhki & Antonino Giordano & Chiara Starvaggi Cucuzza & Tejaswi Venkata S. Badam & Samudyata Samudyata & Marianne Victoria Lemée & Pernilla Stridh & Asimenia Gkogka & Klementy Shchetyns, 2024. "A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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