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PD-L1hi B cells are critical regulators of humoral immunity

Author

Listed:
  • Adnan R. Khan

    (Translational Immunology Group, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin)

  • Emily Hams

    (Translational Immunology Group, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin)

  • Achilleas Floudas

    (Translational Immunology Group, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin)

  • Tim Sparwasser

    (Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI))

  • Casey T. Weaver

    (University of Alabama)

  • Padraic G. Fallon

    (Translational Immunology Group, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin
    National Children’s Research Centre, Our Lady’s Children’s Hospital
    Institute of Molecular Medicine, School of Medicine St James’s Hospital, Trinity College Dublin)

Abstract

Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However, Breg cell mediated immune suppression, independent of IL-10, also occurs. Here we show that Breg cells play a critical role in regulating humoral immunity mediated by CD4+CXCR5+PD-1+ follicular helper T cells, and can suppress inflammation in autoimmune disease through elevated expression of PD-L1. We have also identified that these B cells are resistant to αCD20 B-cell depletion. This work describes how Breg cells are critical in humoral homoeostasis and may have implications for the regulation of autoimmune diseases.

Suggested Citation

  • Adnan R. Khan & Emily Hams & Achilleas Floudas & Tim Sparwasser & Casey T. Weaver & Padraic G. Fallon, 2015. "PD-L1hi B cells are critical regulators of humoral immunity," Nature Communications, Nature, vol. 6(1), pages 1-16, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6997
    DOI: 10.1038/ncomms6997
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    Cited by:

    1. Akshay J. Patel & Zena N. Willsmore & Naeem Khan & Alex Richter & Babu Naidu & Mark T. Drayson & Sophie Papa & Andrew Cope & Sophia N. Karagiannis & Esperanza Perucha & Gary W. Middleton, 2022. "Regulatory B cell repertoire defects predispose lung cancer patients to immune-related toxicity following checkpoint blockade," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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