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Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex

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  • Yohei Shinmyo

    (Faculty of Life Sciences, Kumamoto University
    Graduate School of Medical Sciences, Kanazawa University, Takara-machi 13-1, Ishikawa 920–8640, Japan)

  • M. Asrafuzzaman Riyadh

    (Faculty of Life Sciences, Kumamoto University)

  • Giasuddin Ahmed

    (Faculty of Life Sciences, Kumamoto University)

  • Iftekhar Bin Naser

    (Faculty of Life Sciences, Kumamoto University)

  • Mahmud Hossain

    (Faculty of Life Sciences, Kumamoto University)

  • Hirohide Takebayashi

    (Graduate School of Medical and Dental Sciences, Niigata University)

  • Hiroshi Kawasaki

    (Graduate School of Medical Sciences, Kanazawa University, Takara-machi 13-1, Ishikawa 920–8640, Japan
    Brain/Liver Interface Medicine Research Center, Kanazawa University)

  • Kunimasa Ohta

    (Faculty of Life Sciences, Kumamoto University)

  • Hideaki Tanaka

    (Faculty of Life Sciences, Kumamoto University)

Abstract

The thalamocortical tract carries sensory information to the neocortex. It has long been recognized that the neocortical pioneer axons of subplate neurons are essential for thalamocortical development. Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons, including subplate neurons, and is necessary for thalamocortical development. In draxin−/− mice, thalamocortical axons do not enter the neocortex. This phenotype is sufficiently rescued by the transgenic expression of draxin in neocortical neurons. Genetic interaction data suggest that draxin acts through Deleted in colorectal cancer (DCC) and Neogenin (Neo1), to regulate thalamocortical projections in vivo. Draxin promotes the outgrowth of thalamic axons in vitro and this effect is abolished in thalamic neurons from Dcc and Neo1 double mutants. These results suggest that draxin from neocortical neurons controls thalamocortical projections into the neocortex, and that this effect is mediated through the DCC and Neo1 receptors.

Suggested Citation

  • Yohei Shinmyo & M. Asrafuzzaman Riyadh & Giasuddin Ahmed & Iftekhar Bin Naser & Mahmud Hossain & Hirohide Takebayashi & Hiroshi Kawasaki & Kunimasa Ohta & Hideaki Tanaka, 2015. "Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex," Nature Communications, Nature, vol. 6(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10232
    DOI: 10.1038/ncomms10232
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