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Embryonic transcription is controlled by maternally defined chromatin state

Author

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  • Saartje Hontelez

    (Radboud Institute for Molecular Life Sciences, Faculty of Science, Radboud University)

  • Ila van Kruijsbergen

    (Radboud Institute for Molecular Life Sciences, Faculty of Science, Radboud University)

  • Georgios Georgiou

    (Radboud Institute for Molecular Life Sciences, Faculty of Science, Radboud University)

  • Simon J. van Heeringen

    (Radboud Institute for Molecular Life Sciences, Faculty of Science, Radboud University)

  • Ozren Bogdanovic

    (ARC Center of Excellence in Plant Energy Biology, The University of Western Australia)

  • Ryan Lister

    (ARC Center of Excellence in Plant Energy Biology, The University of Western Australia
    The Harry Perkins Institute of Medical Research)

  • Gert Jan C. Veenstra

    (Radboud Institute for Molecular Life Sciences, Faculty of Science, Radboud University)

Abstract

Histone-modifying enzymes are required for cell identity and lineage commitment, however little is known about the regulatory origins of the epigenome during embryonic development. Here we generate a comprehensive set of epigenome reference maps, which we use to determine the extent to which maternal factors shape chromatin state in Xenopus embryos. Using α-amanitin to inhibit zygotic transcription, we find that the majority of H3K4me3- and H3K27me3-enriched regions form a maternally defined epigenetic regulatory space with an underlying logic of hypomethylated islands. This maternal regulatory space extends to a substantial proportion of neurula stage-activated promoters. In contrast, p300 recruitment to distal regulatory regions requires embryonic transcription at most loci. The results show that H3K4me3 and H3K27me3 are part of a regulatory space that exerts an extended maternal control well into post-gastrulation development, and highlight the combinatorial action of maternal and zygotic factors through proximal and distal regulatory sequences.

Suggested Citation

  • Saartje Hontelez & Ila van Kruijsbergen & Georgios Georgiou & Simon J. van Heeringen & Ozren Bogdanovic & Ryan Lister & Gert Jan C. Veenstra, 2015. "Embryonic transcription is controlled by maternally defined chromatin state," Nature Communications, Nature, vol. 6(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10148
    DOI: 10.1038/ncomms10148
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    Cited by:

    1. Thao Nguyen & Eli J. Costa & Tim Deibert & Jose Reyes & Felix C. Keber & Miroslav Tomschik & Michael Stadlmeier & Meera Gupta & Chirag K. Kumar & Edward R. Cruz & Amanda Amodeo & Jesse C. Gatlin & Mar, 2022. "Differential nuclear import sets the timing of protein access to the embryonic genome," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Jiankai Wei & Wei Zhang & An Jiang & Hongzhe Peng & Quanyong Zhang & Yuting Li & Jianqing Bi & Linting Wang & Penghui Liu & Jing Wang & Yonghang Ge & Liya Zhang & Haiyan Yu & Lei Li & Shi Wang & Liang, 2024. "Temporospatial hierarchy and allele-specific expression of zygotic genome activation revealed by distant interspecific urochordate hybrids," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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