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Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential

Author

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  • Sayantan Chakraborty

    (Ludwig-Maximilians-University, Munich, Center for Integrated Protein Science Munich—CIPSM, LMU Biocenter, Planegg-Martinsried)

  • Eric J. Lambie

    (Ludwig-Maximilians-University, Munich, Center for Integrated Protein Science Munich—CIPSM, LMU Biocenter, Planegg-Martinsried)

  • Samik Bindu

    (Ludwig-Maximilians-University, Munich, Center for Integrated Protein Science Munich—CIPSM, LMU Biocenter, Planegg-Martinsried
    5841 S. Maryland Ave., Chicago, Illinosis)

  • Tamara Mikeladze-Dvali

    (Ludwig-Maximilians-University, Munich, Center for Integrated Protein Science Munich—CIPSM, LMU Biocenter, Planegg-Martinsried)

  • Barbara Conradt

    (Ludwig-Maximilians-University, Munich, Center for Integrated Protein Science Munich—CIPSM, LMU Biocenter, Planegg-Martinsried)

Abstract

Components of the conserved engulfment pathways promote programmed cell death in Caenorhabditis elegans (C. elegans) through an unknown mechanism. Here we report that the phagocytic receptor CED-1 mEGF10 is required for the formation of a dorsal–ventral gradient of CED-3 caspase activity within the mother of a cell programmed to die and an increase in the level of CED-3 protein within its dying daughter. Furthermore, CED-1 becomes enriched on plasma membrane regions of neighbouring cells that appose the dorsal side of the mother, which later forms the dying daughter. Therefore, we propose that components of the engulfment pathways promote programmed cell death by enhancing the polar localization of apoptotic factors in mothers of cells programmed to die and the unequal segregation of apoptotic potential into dying and surviving daughters. Our findings reveal a novel function of the engulfment pathways and provide a better understanding of how apoptosis is initiated during C. elegans development.

Suggested Citation

  • Sayantan Chakraborty & Eric J. Lambie & Samik Bindu & Tamara Mikeladze-Dvali & Barbara Conradt, 2015. "Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10126
    DOI: 10.1038/ncomms10126
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    Cited by:

    1. Nadin Memar & Ryan Sherrard & Aditya Sethi & Carla Lloret Fernandez & Henning Schmidt & Eric J. Lambie & Richard J. Poole & Ralf Schnabel & Barbara Conradt, 2024. "The replicative helicase CMG is required for the divergence of cell fates during asymmetric cell division in vivo," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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