IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms10106.html
   My bibliography  Save this article

DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression

Author

Listed:
  • Aliza P. Wingo

    (Atlanta VA Medical Center
    School of Medicine, Emory University)

  • Lynn M. Almli

    (School of Medicine, Emory University)

  • Jennifer S. Stevens

    (School of Medicine, Emory University)

  • Torsten Klengel

    (School of Medicine, Emory University
    McLean Hospital, Harvard Medical School)

  • Monica Uddin

    (University of Illinois at Urbana-Champaign
    Carl R. Woese Institute for Genomic Biology)

  • Yujing Li

    (School of Medicine, Emory University)

  • Angela C. Bustamante

    (University of Illinois at Urbana-Champaign)

  • Adriana Lori

    (School of Medicine, Emory University)

  • Nastassja Koen

    (University of Cape Town)

  • Dan J. Stein

    (University of Cape Town)

  • Alicia K. Smith

    (School of Medicine, Emory University)

  • Allison E. Aiello

    (School of Global Public Health, University of North Carolina at Chapel Hill)

  • Karestan C. Koenen

    (Harvard T.H. Chan School of Public Health)

  • Derek E. Wildman

    (University of Illinois at Urbana-Champaign)

  • Sandro Galea

    (School of Public Health, Boston University)

  • Bekh Bradley

    (Atlanta VA Medical Center
    School of Medicine, Emory University)

  • Elisabeth B. Binder

    (School of Medicine, Emory University)

  • Peng Jin

    (School of Medicine, Emory University)

  • Greg Gibson

    (Center for Integrative Genomics, School of Biology, Georgia Institute of Technology)

  • Kerry J. Ressler

    (School of Medicine, Emory University
    McLean Hospital, Harvard Medical School)

Abstract

DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. Our follow-up studies find that lower blood DICER1 expression is significantly associated with increased amygdala activation to fearful stimuli, a neural correlate for PTSD. Additionally, a genetic variant in the 3′ un-translated region of DICER1, rs10144436, is significantly associated with DICER1 expression and with PTSD&Dep, and the latter is replicated in an independent cohort. Furthermore, genome-wide differential expression survey of miRNAs in blood in PTSD&Dep reveals miRNAs to be significantly downregulated in cases versus controls. Together, our novel data suggest DICER1 plays a role in molecular mechanisms of PTSD&Dep through the DICER1 and the miRNA regulation pathway.

Suggested Citation

  • Aliza P. Wingo & Lynn M. Almli & Jennifer S. Stevens & Torsten Klengel & Monica Uddin & Yujing Li & Angela C. Bustamante & Adriana Lori & Nastassja Koen & Dan J. Stein & Alicia K. Smith & Allison E. A, 2015. "DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression," Nature Communications, Nature, vol. 6(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10106
    DOI: 10.1038/ncomms10106
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms10106
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms10106?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10106. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.