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A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of theranostic agents

Author

Listed:
  • Hai Wang

    (The Ohio State University
    Comprehensive Cancer Center, The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

  • Pranay Agarwal

    (The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

  • Shuting Zhao

    (The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

  • Jianhua Yu

    (Comprehensive Cancer Center, The Ohio State University
    The Ohio State University)

  • Xiongbin Lu

    (University of Texas MD Anderson Cancer Center)

  • Xiaoming He

    (The Ohio State University
    Comprehensive Cancer Center, The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

Abstract

Nanoparticles have demonstrated great potential for enhancing drug delivery. However, the low drug encapsulation efficiency at high drug-to-nanoparticle feeding ratios and minimal drug loading content in nanoparticle at any feeding ratios are major hurdles to their widespread applications. Here we report a robust eukaryotic cell-like hybrid nanoplatform (EukaCell) for encapsulation of theranostic agents (doxorubicin and indocyanine green). The EukaCell consists of a phospholipid membrane, a cytoskeleton-like mesoporous silica matrix and a nucleus-like fullerene core. At high drug-to-nanoparticle feeding ratios (for example, 1:0.5), the encapsulation efficiency and loading content can be improved by 58 and 21 times, respectively, compared with conventional silica nanoparticles. Moreover, release of the encapsulated drug can be precisely controlled via dosing near infrared laser irradiation. Ultimately, the ultra-high (up to ∼87%) loading content renders augmented anticancer capacity both in vitro and in vivo. Our EukaCell is valuable for drug delivery to fight against cancer and potentially other diseases.

Suggested Citation

  • Hai Wang & Pranay Agarwal & Shuting Zhao & Jianhua Yu & Xiongbin Lu & Xiaoming He, 2015. "A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of theranostic agents," Nature Communications, Nature, vol. 6(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10081
    DOI: 10.1038/ncomms10081
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