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MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours

Author

Listed:
  • Elizabeth J. Perlman

    (Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University’s Feinberg School of Medicine)

  • Samantha Gadd

    (Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University’s Feinberg School of Medicine)

  • Stefan T. Arold

    (King Abdullah University of Science and Technology, Computational Bioscience Research Center)

  • Anand Radhakrishnan

    (King Abdullah University of Science and Technology, Computational Bioscience Research Center)

  • Daniela S. Gerhard

    (Office of Cancer Genomics, National Cancer Institute)

  • Lawrence Jennings

    (Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University’s Feinberg School of Medicine)

  • Vicki Huff

    (The University of Texas MD Anderson Cancer Center)

  • Jaime M. Guidry Auvil

    (Office of Cancer Genomics, National Cancer Institute)

  • Tanja M. Davidsen

    (Office of Cancer Genomics, National Cancer Institute)

  • Jeffrey S. Dome

    (Children’s National Medical Center)

  • Daoud Meerzaman

    (Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health)

  • Chih Hao Hsu

    (Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health)

  • Cu Nguyen

    (Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health)

  • James Anderson

    (Frontier Science and Technology Research Foundation)

  • Yussanne Ma

    (Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency)

  • Andrew J. Mungall

    (Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency)

  • Richard A. Moore

    (Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency)

  • Marco A. Marra

    (Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency)

  • Charles G. Mullighan

    (St Jude Children’s Research Hospital)

  • Jing Ma

    (St Jude Children’s Research Hospital)

  • David A. Wheeler

    (Nationwide Children's Hospital, Ohio State University College of Medicine)

  • Oliver A. Hampton

    (Nationwide Children's Hospital, Ohio State University College of Medicine)

  • Julie M. Gastier-Foster

    (Baylor College of Medicine
    Ohio State University College of Medicine)

  • Nicole Ross

    (Baylor College of Medicine)

  • Malcolm A. Smith

    (Cancer Therapy Evaluation Program, National Cancer Institute)

Abstract

Wilms tumour is an embryonal tumour of childhood that closely resembles the developing kidney. Genomic changes responsible for the development of the majority of Wilms tumours remain largely unknown. Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. The mutant MLLT1 protein shows altered binding to acetylated histone tails. Moreover, MLLT1-mutant tumours show an increase in MYC gene expression and HOX dysregulation. Patients with MLLT1-mutant tumours present at a younger age and have a high prevalence of precursor intralobar nephrogenic rests. These data support a model whereby activating MLLT1 mutations early in renal development result in the development of Wilms tumour.

Suggested Citation

  • Elizabeth J. Perlman & Samantha Gadd & Stefan T. Arold & Anand Radhakrishnan & Daniela S. Gerhard & Lawrence Jennings & Vicki Huff & Jaime M. Guidry Auvil & Tanja M. Davidsen & Jeffrey S. Dome & Daoud, 2015. "MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours," Nature Communications, Nature, vol. 6(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10013
    DOI: 10.1038/ncomms10013
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    Cited by:

    1. Lele Song & Qinglan Li & Lingbo Xia & Arushi Eesha Sahay & Qi Qiu & Yuanyuan Li & Haitao Li & Kotaro Sasaki & Katalin Susztak & Hao Wu & Liling Wan, 2024. "Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape," Nature Communications, Nature, vol. 15(1), pages 1-26, December.

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