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Enrichment of CD56dimKIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients

Author

Listed:
  • Talib Hassan Ali

    (University of Catanzaro ‘Magna Graecia’
    College of Medicine, University of Thi-Qar)

  • Simona Pisanti

    (University of Salerno, Baronissi Campus
    University of Salerno)

  • Elena Ciaglia

    (University of Salerno, Baronissi Campus
    University of Salerno)

  • Roberta Mortarini

    (Human Tumors Immunobiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori)

  • Andrea Anichini

    (Human Tumors Immunobiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori)

  • Cinzia Garofalo

    (University of Catanzaro ‘Magna Graecia’)

  • Rossana Tallerico

    (University of Catanzaro ‘Magna Graecia’)

  • Mario Santinami

    (Melanoma and Sarcoma Unit, Fondazione IRCCS Istituto Nazionale dei Tumori)

  • Elio Gulletta

    (University of Catanzaro ‘Magna Graecia’)

  • Caterina Ietto

    (University of Catanzaro ‘Magna Graecia’)

  • Mario Galgani

    (Istituto di Endocrinologia e Oncologia Sperimentale, IEOS-CNR, Università di Napoli Federico II)

  • Giuseppe Matarese

    (University of Salerno, Baronissi Campus
    IRCCS Multimedica)

  • Maurizio Bifulco

    (University of Salerno, Baronissi Campus
    University of Salerno)

  • Soldano Ferrone

    (Harvard Medical School)

  • Francesco Colucci

    (University of Cambridge Clinical School, NIHR Cambridge Biomedical Research Centre)

  • Alessandro Moretta

    (Laboratory of Molecular Immunology, University of Genova)

  • Klas Kärre

    (Karolinska Institute)

  • Ennio Carbone

    (University of Catanzaro ‘Magna Graecia’
    Karolinska Institute)

Abstract

An important checkpoint in the progression of melanoma is the metastasis to lymph nodes. Here, to investigate the role of lymph node NK cells in disease progression, we analyze frequency, phenotype and functions of NK cells from tumour-infiltrated (TILN) and tumour-free ipsilateral lymph nodes (TFLN) of the same patients. We show an expansion of CD56dimCD57dimCD69+CCR7+KIR+ NK cells in TILN. TILN NK cells display robust cytotoxic activity against autologous melanoma cells. In the blood of metastatic melanoma patients, the frequency of NK cells expressing the receptors for CXCL8 receptor is increased compared with healthy subjects, and blood NK cells also express the receptors for CCL2 and IL-6. These factors are produced in high amount in TILN and in vitro switch the phenotype of blood NK cells from healthy donors to the phenotype associated with TILN. Our data suggest that the microenvironment of TILN generates and/or recruits a particularly effective NK cell subset.

Suggested Citation

  • Talib Hassan Ali & Simona Pisanti & Elena Ciaglia & Roberta Mortarini & Andrea Anichini & Cinzia Garofalo & Rossana Tallerico & Mario Santinami & Elio Gulletta & Caterina Ietto & Mario Galgani & Giuse, 2014. "Enrichment of CD56dimKIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients," Nature Communications, Nature, vol. 5(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6639
    DOI: 10.1038/ncomms6639
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    Cited by:

    1. James J. Gilchrist & Seiko Makino & Vivek Naranbhai & Piyush K. Sharma & Surya Koturan & Orion Tong & Chelsea A. Taylor & Robert A. Watson & Alba Verge los Aires & Rosalin Cooper & Evelyn Lau & Sara D, 2022. "Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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