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Genomic identification and characterization of the pseudoautosomal region in highly differentiated avian sex chromosomes

Author

Listed:
  • Linnéa Smeds

    (Evolutionary Biology Centre, Uppsala University)

  • Takeshi Kawakami

    (Evolutionary Biology Centre, Uppsala University)

  • Reto Burri

    (Evolutionary Biology Centre, Uppsala University)

  • Paulina Bolivar

    (Evolutionary Biology Centre, Uppsala University)

  • Arild Husby

    (Evolutionary Biology Centre, Uppsala University
    Norwegian University of Science and Technology)

  • Anna Qvarnström

    (Evolutionary Biology Centre, Uppsala University)

  • Severin Uebbing

    (Evolutionary Biology Centre, Uppsala University)

  • Hans Ellegren

    (Evolutionary Biology Centre, Uppsala University)

Abstract

The molecular characteristics of the pseudoautosomal region (PAR) of sex chromosomes remain elusive. Despite significant genome-sequencing efforts, the PAR of highly differentiated avian sex chromosomes remains to be identified. Here we use linkage analysis together with whole-genome re-sequencing to uncover the 630-kb PAR of an ecological model species, the collared flycatcher. The PAR contains 22 protein-coding genes and is GC rich. The genetic length is 64 cM in female meiosis, consistent with an obligate crossing-over event. Recombination is concentrated to a hotspot region, with an extreme rate of >700 cM/Mb in a 67-kb segment. We find no signatures of sexual antagonism and propose that sexual antagonism may have limited influence on PAR sequences when sex chromosomes are nearly fully differentiated and when a recombination hotspot region is located close to the PAR boundary. Our results demonstrate that a very small PAR suffices to ensure homologous recombination and proper segregation of sex chromosomes during meiosis.

Suggested Citation

  • Linnéa Smeds & Takeshi Kawakami & Reto Burri & Paulina Bolivar & Arild Husby & Anna Qvarnström & Severin Uebbing & Hans Ellegren, 2014. "Genomic identification and characterization of the pseudoautosomal region in highly differentiated avian sex chromosomes," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6448
    DOI: 10.1038/ncomms6448
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    Cited by:

    1. Lulu Xu & Yandong Ren & Jiahong Wu & Tingting Cui & Rong Dong & Chen Huang & Zhe Feng & Tianmin Zhang & Peng Yang & Jiaqing Yuan & Xiao Xu & Jiao Liu & Jinhong Wang & Wu Chen & Da Mi & David M. Irwin , 2024. "Evolution and expression patterns of the neo-sex chromosomes of the crested ibis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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