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Bacterial effector modulation of host E3 ligase activity suppresses PAMP-triggered immunity in rice

Author

Listed:
  • Kazuya Ishikawa

    (Graduate School of Agriculture, Kinki University)

  • Koji Yamaguchi

    (Graduate School of Agriculture, Kinki University)

  • Kazuaki Sakamoto

    (Graduate School of Agriculture, Kinki University)

  • Satomi Yoshimura

    (Graduate School of Agriculture, Kinki University)

  • Kento Inoue

    (Graduate School of Agriculture, Kinki University)

  • Seiji Tsuge

    (Graduate School of Life and Environmental Science, Kyoto Prefectural University)

  • Chojiro Kojima

    (Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Tsutomu Kawasaki

    (Graduate School of Agriculture, Kinki University)

Abstract

Pathogen effector proteins are delivered to host cells to suppress plant immunity. However, the mechanisms by which effector proteins function are largely unknown. Here we show that expression of XopPXoo, an effector of rice pathogen Xanthomonas oryzae pv. oryzae, in rice strongly suppresses peptidoglycan (PGN)- and chitin-triggered immunity and resistance to X. oryzae. XopPXoo targets OsPUB44, a rice ubiquitin E3 ligase with a unique U-box domain. We find that XopPXoo directly interacts with the OsPUB44 U-box domain and inhibits ligase activity. Two amino-acid residues specific for the OsPUB44 U-box domain are identified, which are responsible for the interaction with XopPXoo. Silencing of OsPUB44 suppresses PGN- and chitin-triggered immunity and X. oryzae resistance, indicating that OsPUB44 positively regulates immune responses. Thus, it is likely that XopPXoo suppresses immune responses by directly interacting with and inhibiting a positive regulator of plant immunity.

Suggested Citation

  • Kazuya Ishikawa & Koji Yamaguchi & Kazuaki Sakamoto & Satomi Yoshimura & Kento Inoue & Seiji Tsuge & Chojiro Kojima & Tsutomu Kawasaki, 2014. "Bacterial effector modulation of host E3 ligase activity suppresses PAMP-triggered immunity in rice," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6430
    DOI: 10.1038/ncomms6430
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    Cited by:

    1. Kota Ichimaru & Koji Yamaguchi & Kenichi Harada & Yusaku Nishio & Momoka Hori & Kazuya Ishikawa & Haruhiko Inoue & Shusuke Shigeta & Kento Inoue & Keita Shimada & Satomi Yoshimura & Takumi Takeda & Ei, 2022. "Cooperative regulation of PBI1 and MAPKs controls WRKY45 transcription factor in rice immunity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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