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Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4+ memory T Cells

Author

Listed:
  • S. Jaafoura

    (INSERM U1012)

  • M. G. de Goër de Herve

    (INSERM U1012)

  • E. A. Hernandez-Vargas

    (Systems Medicine of Infectious Diseases, Helmholtz Centre for Infection Research, Inhoffenstraße 7)

  • H. Hendel-Chavez

    (INSERM U1012)

  • M. Abdoh

    (INSERM U1012)

  • M. C. Mateo

    (INSERM U1012)

  • R. Krzysiek

    (INSERM U996
    Faculté de Médecine, Université Paris-Sud)

  • M. Merad

    (Institut Gustave Roussy)

  • R. Seng

    (INSERM U1018)

  • M. Tardieu

    (INSERM U1012
    Faculté de Médecine, Université Paris-Sud)

  • J. F. Delfraissy

    (INSERM U1012
    Faculté de Médecine, Université Paris-Sud
    Hôpitaux Universitaires Paris-Sud)

  • C. Goujard

    (Faculté de Médecine, Université Paris-Sud
    Institut Gustave Roussy
    Hôpitaux Universitaires Paris-Sud)

  • Y. Taoufik

    (INSERM U1012
    Faculté de Médecine, Université Paris-Sud)

Abstract

In patients who are receiving prolonged antiretroviral treatment (ART), HIV can persist within a small pool of long-lived resting memory CD4+ T cells infected with integrated latent virus. This latent reservoir involves distinct memory subsets. Here we provide results that suggest a progressive reduction of the size of the blood latent reservoir around a core of less-differentiated memory subsets (central memory and stem cell-like memory (TSCM) CD4+ T cells). This process appears to be driven by the differences in initial sizes and decay rates between latently infected memory subsets. Our results also suggest an extreme stability of the TSCM sub-reservoir, the size of which is directly related to cumulative plasma virus exposure before the onset of ART, stressing the importance of early initiation of effective ART. The presence of these intrinsic dynamics within the latent reservoir may have implications for the design of optimal HIV therapeutic purging strategies.

Suggested Citation

  • S. Jaafoura & M. G. de Goër de Herve & E. A. Hernandez-Vargas & H. Hendel-Chavez & M. Abdoh & M. C. Mateo & R. Krzysiek & M. Merad & R. Seng & M. Tardieu & J. F. Delfraissy & C. Goujard & Y. Taoufik, 2014. "Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4+ memory T Cells," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6407
    DOI: 10.1038/ncomms6407
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    Cited by:

    1. Caroline Dufour & Corentin Richard & Marion Pardons & Marta Massanella & Antoine Ackaoui & Ben Murrell & Bertrand Routy & Réjean Thomas & Jean-Pierre Routy & Rémi Fromentin & Nicolas Chomont, 2023. "Phenotypic characterization of single CD4+ T cells harboring genetically intact and inducible HIV genomes," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Daniel B. Reeves & Charline Bacchus-Souffan & Mark Fitch & Mohamed Abdel-Mohsen & Rebecca Hoh & Haelee Ahn & Mars Stone & Frederick Hecht & Jeffrey Martin & Steven G. Deeks & Marc K. Hellerstein & Jos, 2023. "Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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