IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms6342.html
   My bibliography  Save this article

Evidence for henipavirus spillover into human populations in Africa

Author

Listed:
  • Olivier Pernet

    (Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA)

  • Bradley S. Schneider

    (Global Viral/Metabiota Laboratory Sciences)

  • Shannon M. Beaty

    (Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
    Icahn School of Medicine at Mount Sinai)

  • Matthew LeBreton

    (Global Viral/Metabiota Laboratory Sciences)

  • Tatyana E. Yun

    (University of Texas Medical Branch)

  • Arnold Park

    (Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
    Icahn School of Medicine at Mount Sinai)

  • Trevor T. Zachariah

    (Brevard Zoo Veterinary Services, Brevard Zoo)

  • Thomas A. Bowden

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Peta Hitchens

    (School of Veterinary Medicine, UC Davis)

  • Christina M. Ramirez

    (School of Public Health, UCLA)

  • Peter Daszak

    (EcoHealth Alliance)

  • Jonna Mazet

    (School of Veterinary Medicine, UC Davis)

  • Alexander N. Freiberg

    (University of Texas Medical Branch)

  • Nathan D. Wolfe

    (Global Viral/Metabiota Laboratory Sciences)

  • Benhur Lee

    (Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
    Icahn School of Medicine at Mount Sinai)

Abstract

Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to humans has only been reported in Australia and South/Southeast Asia. However, a recent study discovered numerous HNV clades in African bat samples. To determine the potential for HNV spillover events among humans in Africa, here we examine well-curated sets of bat (Eidolon helvum, n=44) and human (n=497) serum samples from Cameroon for Nipah virus (NiV) cross-neutralizing antibodies (NiV-X-Nabs). Using a vesicular stomatitis virus (VSV)-based pseudoparticle seroneutralization assay, we detect NiV-X-Nabs in 48% and 3–4% of the bat and human samples, respectively. Seropositive human samples are found almost exclusively in individuals who reported butchering bats for bushmeat. Seropositive human sera also neutralize Hendra virus and Gh-M74a (an African HNV) pseudoparticles, as well as live NiV. Butchering bat meat and living in areas undergoing deforestation are the most significant risk factors associated with seropositivity. Evidence for HNV spillover events warrants increased surveillance efforts.

Suggested Citation

  • Olivier Pernet & Bradley S. Schneider & Shannon M. Beaty & Matthew LeBreton & Tatyana E. Yun & Arnold Park & Trevor T. Zachariah & Thomas A. Bowden & Peta Hitchens & Christina M. Ramirez & Peter Dasza, 2014. "Evidence for henipavirus spillover into human populations in Africa," Nature Communications, Nature, vol. 5(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6342
    DOI: 10.1038/ncomms6342
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms6342
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms6342?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ariel Isaacs & Yu Shang Low & Kyle L. Macauslane & Joy Seitanidou & Cassandra L. Pegg & Stacey T. M. Cheung & Benjamin Liang & Connor A. P. Scott & Michael J. Landsberg & Benjamin L. Schulz & Keith J., 2023. "Structure and antigenicity of divergent Henipavirus fusion glycoproteins," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6342. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.