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Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

Author

Listed:
  • Dong-Wook Park

    (University of Wisconsin—Madison)

  • Amelia A. Schendel

    (Materials Science Program, University of Wisconsin—Madison)

  • Solomon Mikael

    (University of Wisconsin—Madison)

  • Sarah K. Brodnick

    (University of Wisconsin—Madison)

  • Thomas J. Richner

    (University of Wisconsin—Madison)

  • Jared P. Ness

    (University of Wisconsin—Madison)

  • Mohammed R. Hayat

    (University of Wisconsin—Madison)

  • Farid Atry

    (University of Wisconsin—Milwaukee)

  • Seth T. Frye

    (University of Wisconsin—Milwaukee)

  • Ramin Pashaie

    (University of Wisconsin—Milwaukee)

  • Sanitta Thongpang

    (Mahidol University)

  • Zhenqiang Ma

    (University of Wisconsin—Madison
    Materials Science Program, University of Wisconsin—Madison)

  • Justin C. Williams

    (Materials Science Program, University of Wisconsin—Madison
    University of Wisconsin—Madison)

Abstract

Neural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its utility through optical interface experiments that use this broad spectrum transparency. These include optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography. This study demonstrates an array of interfacing abilities of the CLEAR device and its utility for neural applications.

Suggested Citation

  • Dong-Wook Park & Amelia A. Schendel & Solomon Mikael & Sarah K. Brodnick & Thomas J. Richner & Jared P. Ness & Mohammed R. Hayat & Farid Atry & Seth T. Frye & Ramin Pashaie & Sanitta Thongpang & Zhenq, 2014. "Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6258
    DOI: 10.1038/ncomms6258
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    Cited by:

    1. Lawrence Coles & Domenico Ventrella & Alejandro Carnicer-Lombarte & Alberto Elmi & Joe G. Troughton & Massimo Mariello & Salim El Hadwe & Ben J. Woodington & Maria L. Bacci & George G. Malliaras & Dam, 2024. "Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Jung Min Lee & Young-Woo Pyo & Yeon Jun Kim & Jin Hee Hong & Yonghyeon Jo & Wonshik Choi & Dingchang Lin & Hong-Gyu Park, 2023. "The ultra-thin, minimally invasive surface electrode array NeuroWeb for probing neural activity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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