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Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis

Author

Listed:
  • Ming Tang

    (Johns Hopkins University School of Medicine)

  • Mingjie Wang

    (Johns Hopkins University School of Medicine
    Fudan University Shanghai Medical College)

  • Changji Shi

    (Johns Hopkins University)

  • Pablo A. Iglesias

    (Johns Hopkins University School of Medicine
    Johns Hopkins University)

  • Peter N. Devreotes

    (Johns Hopkins University School of Medicine)

  • Chuan-Hsiang Huang

    (Johns Hopkins University School of Medicine)

Abstract

Numerous models explain how cells sense and migrate towards shallow chemoattractant gradients. Studies show that an excitable signal transduction network acts as a pacemaker that controls the cytoskeleton to drive motility. Here we show that this network is required to link stimuli to actin polymerization and chemotactic motility and we distinguish the various models of chemotaxis. First, signalling activity is suppressed towards the low side in a gradient or following removal of uniform chemoattractant. Second, signalling activities display a rapid shut off and a slower adaptation during which responsiveness to subsequent test stimuli decline. Simulations of various models indicate that these properties require coupled adaptive and excitable networks. Adaptation involves a G-protein-independent inhibitor, as stimulation of cells lacking G-protein function suppresses basal activities. The salient features of the coupled networks were observed for different chemoattractants in Dictyostelium and in human neutrophils, suggesting an evolutionarily conserved mechanism for eukaryotic chemotaxis.

Suggested Citation

  • Ming Tang & Mingjie Wang & Changji Shi & Pablo A. Iglesias & Peter N. Devreotes & Chuan-Hsiang Huang, 2014. "Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis," Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6175
    DOI: 10.1038/ncomms6175
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    Cited by:

    1. George R. R. Bell & Esther Rincón & Emel Akdoğan & Sean R. Collins, 2021. "Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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