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Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

Author

Listed:
  • Beben Benyamin

    (The University of Queensland, Queensland Brain Institute
    QIMR Berghofer Medical Research Institute)

  • Tonu Esko

    (Estonian Genome Center, University of Tartu
    The Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Janina S. Ried

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstraße 1)

  • Aparna Radhakrishnan

    (University of Cambridge)

  • Sita H. Vermeulen

    (Radboud University Medical Centre
    Radboud University Medical Centre)

  • Michela Traglia

    (San Raffaele Scientific Institute
    Institute for Maternal and Child Health-IRCCS ‘‘Burlo Garofolo’’- Trieste)

  • Martin Gögele

    (Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC))

  • Denise Anderson

    (Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia)

  • Linda Broer

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Clara Podmore

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus)

  • Jian’an Luan

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus)

  • Zoltan Kutalik

    (Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)
    Swiss Institute of Bioinformatics)

  • Serena Sanna

    (Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato)

  • Peter van der Meer

    (University of Groningen, University Medical Center Groningen)

  • Toshiko Tanaka

    (Translational Gerontology Branch, National Institute on Aging)

  • Fudi Wang

    (School of Public Health, Zhejiang University)

  • Harm-Jan Westra

    (University Medical Center Groningen)

  • Lude Franke

    (University Medical Center Groningen)

  • Evelin Mihailov

    (Estonian Genome Center, University of Tartu
    Institute of Molecular and Cell Biology, University of Tartu)

  • Lili Milani

    (Estonian Genome Center, University of Tartu)

  • Jonas Hälldin

    (Estonian Genome Center, University of Tartu)

  • Juliane Winkelmann

    (Stanford University
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München
    Institut für Humangenetik, Helmholtz Zentrum München
    Munich Cluster for Systems Neurology (SyNergy))

  • Thomas Meitinger

    (Institut für Humangenetik, Helmholtz Zentrum München
    Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München)

  • Joachim Thiery

    (Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig
    LIFE Research Center for Civilization Diseases, Medical Faculty, University Leipzig)

  • Annette Peters

    (Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health)

  • Melanie Waldenberger

    (Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health)

  • Augusto Rendon

    (University of Cambridge
    NHS Blood and Transplant, Cambridge Biomedical Campus
    Medical Research Council Biostatistics Unit, Cambridge Biomedical Campus)

  • Jennifer Jolley

    (University of Cambridge
    NHS Blood and Transplant, Cambridge Biomedical Campus)

  • Jennifer Sambrook

    (University of Cambridge
    NHS Blood and Transplant, Cambridge Biomedical Campus)

  • Lambertus A. Kiemeney

    (Radboud University Medical Centre
    Radboud University Medical Centre)

  • Fred C. Sweep

    (Laboratory of Genetic, Endocrine and Metabolic Diseases (LGEM), Radboud University Medical Centre)

  • Cinzia F. Sala

    (San Raffaele Scientific Institute)

  • Christine Schwienbacher

    (Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC))

  • Irene Pichler

    (Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC))

  • Jennie Hui

    (PathWest Laboratory Medicine of WA
    Schools of Pathology and Laboratory Medicine, and Population Health, The University of Western Australia)

  • Ayse Demirkan

    (Erasmus Medical Center
    Leiden University Medical Center)

  • Aaron Isaacs

    (Erasmus Medical Center
    Center of Medical Systems Biology)

  • Najaf Amin

    (Erasmus Medical Center)

  • Maristella Steri

    (Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato)

  • Gérard Waeber

    (Internal Medicine, CHUV, University of Lausanne)

  • Niek Verweij

    (University of Groningen, University Medical Center Groningen)

  • Joseph E. Powell

    (The University of Queensland, Queensland Brain Institute
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Dale R. Nyholt

    (QIMR Berghofer Medical Research Institute)

  • Andrew C. Heath

    (Washington University, 660S Euclid Avenue)

  • Pamela A. F. Madden

    (Washington University, 660S Euclid Avenue)

  • Peter M. Visscher

    (The University of Queensland, Queensland Brain Institute
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital)

  • Margaret J. Wright

    (QIMR Berghofer Medical Research Institute)

  • Grant W. Montgomery

    (QIMR Berghofer Medical Research Institute)

  • Nicholas G. Martin

    (QIMR Berghofer Medical Research Institute)

  • Dena Hernandez

    (Laboratory of Neurogenetics, National Institute on Aging)

  • Stefania Bandinelli

    (Geriatric Unit, Azienda Sanitaria Firenze (ASF))

  • Pim van der Harst

    (University of Groningen, University Medical Center Groningen
    Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute
    University of Groningen, University Medical Center Groningen)

  • Manuela Uda

    (Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato)

  • Peter Vollenweider

    (Internal Medicine, CHUV, University of Lausanne)

  • Robert A. Scott

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus)

  • Claudia Langenberg

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus)

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus)

  • Cornelia van Duijn

    (Erasmus Medical Center
    Center of Medical Systems Biology
    Member of Netherlands Consortium for Healthy Aging sponsored by Netherlands Genomics Initiative, Postbus 9600)

  • John Beilby

    (PathWest Laboratory Medicine of WA
    Schools of Pathology and Laboratory Medicine, and Population Health, The University of Western Australia)

  • Peter P. Pramstaller

    (Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC)
    General Central Hospital)

  • Andrew A. Hicks

    (Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC))

  • Willem H. Ouwehand

    (University of Cambridge
    NHS Blood and Transplant, Cambridge Biomedical Campus)

  • Konrad Oexle

    (Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München)

  • Christian Gieger

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstraße 1
    Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu)

  • Clara Camaschella

    (San Raffaele Scientific Institute
    Vita-Salute University)

  • Daniela Toniolo

    (San Raffaele Scientific Institute)

  • Dorine W. Swinkels

    (Laboratory of Genetic, Endocrine and Metabolic Diseases (LGEM), Radboud University Medical Centre)

  • John B. Whitfield

    (QIMR Berghofer Medical Research Institute)

Abstract

Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-significant (P

Suggested Citation

  • Beben Benyamin & Tonu Esko & Janina S. Ried & Aparna Radhakrishnan & Sita H. Vermeulen & Michela Traglia & Martin Gögele & Denise Anderson & Linda Broer & Clara Podmore & Jian’an Luan & Zoltan Kutalik, 2014. "Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5926
    DOI: 10.1038/ncomms5926
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    Cited by:

    1. Arianna Landini & Irena Trbojević-Akmačić & Pau Navarro & Yakov A. Tsepilov & Sodbo Z. Sharapov & Frano Vučković & Ozren Polašek & Caroline Hayward & Tea Petrović & Marija Vilaj & Yurii S. Aulchenko &, 2022. "Genetic regulation of post-translational modification of two distinct proteins," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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