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The landscape of kinase fusions in cancer

Author

Listed:
  • Nicolas Stransky

    (Blueprint Medicines)

  • Ethan Cerami

    (Blueprint Medicines)

  • Stefanie Schalm

    (Blueprint Medicines)

  • Joseph L. Kim

    (Blueprint Medicines)

  • Christoph Lengauer

    (Blueprint Medicines)

Abstract

Human cancer genomes harbour a variety of alterations leading to the deregulation of key pathways in tumour cells. The genomic characterization of tumours has uncovered numerous genes recurrently mutated, deleted or amplified, but gene fusions have not been characterized as extensively. Here we develop heuristics for reliably detecting gene fusion events in RNA-seq data and apply them to nearly 7,000 samples from The Cancer Genome Atlas. We thereby are able to discover several novel and recurrent fusions involving kinases. These findings have immediate clinical implications and expand the therapeutic options for cancer patients, as approved or exploratory drugs exist for many of these kinases.

Suggested Citation

  • Nicolas Stransky & Ethan Cerami & Stefanie Schalm & Joseph L. Kim & Christoph Lengauer, 2014. "The landscape of kinase fusions in cancer," Nature Communications, Nature, vol. 5(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5846
    DOI: 10.1038/ncomms5846
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    Cited by:

    1. Mrinal M. Gounder & Narasimhan P. Agaram & Sally E. Trabucco & Victoria Robinson & Richard A. Ferraro & Sherri Z. Millis & Anita Krishnan & Jessica Lee & Steven Attia & Wassim Abida & Alexander Drilon, 2022. "Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Swarnendu Tripathi & Hazheen K. Shirnekhi & Scott D. Gorman & Bappaditya Chandra & David W. Baggett & Cheon-Gil Park & Ramiz Somjee & Benjamin Lang & Seyed Mohammad Hadi Hosseini & Brittany J. Pioso &, 2023. "Defining the condensate landscape of fusion oncoproteins," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    3. Gaurav Mendiratta & Eugene Ke & Meraj Aziz & David Liarakos & Melinda Tong & Edward C. Stites, 2021. "Cancer gene mutation frequencies for the U.S. population," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    4. Taek-Chin Cheong & Ahram Jang & Qi Wang & Giulia C. Leonardi & Biagio Ricciuti & Joao V. Alessi & Alessandro Di Federico & Mark M. Awad & Maria K. Lehtinen & Marian H. Harris & Roberto Chiarle, 2024. "Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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