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Respiratory transmission of an avian H3N8 influenza virus isolated from a harbour seal

Author

Listed:
  • Erik A. Karlsson

    (St. Jude Children’s Research Hospital)

  • Hon S. Ip

    (United States Geological Survey, National Wildlife Health Center)

  • Jeffrey S. Hall

    (United States Geological Survey, National Wildlife Health Center)

  • Sun Woo Yoon

    (St. Jude Children’s Research Hospital)

  • Jordan Johnson

    (St. Jude Children’s Research Hospital)

  • Melinda A. Beck

    (Gillings School of Global Public Health, University of North Carolina at Chapel Hill)

  • Richard J. Webby

    (St. Jude Children’s Research Hospital)

  • Stacey Schultz-Cherry

    (St. Jude Children’s Research Hospital)

Abstract

The ongoing human H7N9 influenza infections highlight the threat of emerging avian influenza viruses. In 2011, an avian H3N8 influenza virus isolated from moribund New England harbour seals was shown to have naturally acquired mutations known to increase the transmissibility of highly pathogenic H5N1 influenza viruses. To elucidate the potential human health threat, here we evaluate a panel of avian H3N8 viruses and find that the harbour seal virus displays increased affinity for mammalian receptors, transmits via respiratory droplets in ferrets and replicates in human lung cells. Analysis of a panel of human sera for H3N8 neutralizing antibodies suggests that there is no population-wide immunity to these viruses. The prevalence of H3N8 viruses in birds and multiple mammalian species including recent isolations from pigs and evidence that it was a past human pandemic virus make the need for surveillance and risk analysis of these viruses of public health importance.

Suggested Citation

  • Erik A. Karlsson & Hon S. Ip & Jeffrey S. Hall & Sun Woo Yoon & Jordan Johnson & Melinda A. Beck & Richard J. Webby & Stacey Schultz-Cherry, 2014. "Respiratory transmission of an avian H3N8 influenza virus isolated from a harbour seal," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5791
    DOI: 10.1038/ncomms5791
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    Cited by:

    1. Pengtao Bao & Yang Liu & Xiaoai Zhang & Hang Fan & Jie Zhao & Mi Mu & Haiyang Li & Yanhe Wang & Honghan Ge & Shuang Li & Xin Yang & Qianqian Cui & Rui Chen & Liang Gao & Zhihua Sun & Lizhen Gao & Shua, 2022. "Human infection with a reassortment avian influenza A H3N8 virus: an epidemiological investigation study," Nature Communications, Nature, vol. 13(1), pages 1-8, December.

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