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Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

Author

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  • Takuma Yoshizumi

    (Faculty of Sciences, Kyushu University)

  • Takeshi Ichinohe

    (International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo)

  • Osamu Sasaki

    (Faculty of Sciences, Kyushu University)

  • Hidenori Otera

    (Graduate School of Medical Science, Kyushu University)

  • Shun-ichiro Kawabata

    (Faculty of Sciences, Kyushu University)

  • Katsuyoshi Mihara

    (Graduate School of Medical Science, Kyushu University)

  • Takumi Koshiba

    (Faculty of Sciences, Kyushu University)

Abstract

Mitochondria contribute to cellular innate immunity against RNA viruses. Mitochondrial-mediated innate immunity is regulated by signalling molecules that are recruited to the mitochondrial membrane, and depends on the mitochondrial inner membrane potential (Δψm). Here we examine the physiological relevance of Δψm and the mitochondrial-associating influenza A viral protein PB1-F2 in innate immunity. When expressed in host cells, PB1-F2 completely translocates into the mitochondrial inner membrane space via Tom40 channels, and its accumulation accelerates mitochondrial fragmentation due to reduced Δψm. By contrast, PB1-F2 variants lacking a C-terminal polypeptide, which is frequently found in low pathogenic subtypes, do not affect mitochondrial function. PB1-F2-mediated attenuation of Δψm suppresses the RIG-I signalling pathway and activation of NLRP3 inflammasomes. PB1-F2 translocation into mitochondria strongly correlates with impaired cellular innate immunity, making this translocation event a potential therapeutic target.

Suggested Citation

  • Takuma Yoshizumi & Takeshi Ichinohe & Osamu Sasaki & Hidenori Otera & Shun-ichiro Kawabata & Katsuyoshi Mihara & Takumi Koshiba, 2014. "Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity," Nature Communications, Nature, vol. 5(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5713
    DOI: 10.1038/ncomms5713
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    Cited by:

    1. Katelyn C. Cook & Elene Tsopurashvili & Jason M. Needham & Sunnie R. Thompson & Ileana M. Cristea, 2022. "Restructured membrane contacts rewire organelles for human cytomegalovirus infection," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Hui Yang & Yurui Dong & Ying Bian & Nuo Xu & Yuwei Wu & Fan Yang & Yinping Du & Tao Qin & Sujuan Chen & Daxin Peng & Xiufan Liu, 2022. "The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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