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A smart and versatile theranostic nanomedicine platform based on nanoporphyrin

Author

Listed:
  • Yuanpei Li

    (UC Davis Comprehensive Cancer Center, University of California Davis)

  • Tzu-yin Lin

    (University of California Davis)

  • Yan Luo

    (UC Davis Comprehensive Cancer Center, University of California Davis
    PLA Cancer Research Institute of the Second Affiliated Hospital, Third Military Medical University)

  • Qiangqiang Liu

    (UC Davis Comprehensive Cancer Center, University of California Davis
    National Chengdu Center for Safety Evaluation of Drugs, West China Hospital, Sichuan University)

  • Wenwu Xiao

    (UC Davis Comprehensive Cancer Center, University of California Davis)

  • Wenchang Guo

    (UC Davis Comprehensive Cancer Center, University of California Davis)

  • Diana Lac

    (UC Davis Comprehensive Cancer Center, University of California Davis)

  • Hongyong Zhang

    (University of California Davis)

  • Caihong Feng

    (UC Davis Comprehensive Cancer Center, University of California Davis
    Beijing Institute of Technology)

  • Sebastian Wachsmann-Hogiu

    (NSF Center for Biophotonics Science and Technology, University of California Davis
    University of California Davis)

  • Jeffrey H. Walton

    (UC Davis Comprehensive Cancer Center, University of California Davis
    UC Davis NMR Facility)

  • Simon R. Cherry

    (Center for Molecular and Genomic Imaging, University of California Davis)

  • Douglas J. Rowland

    (Center for Molecular and Genomic Imaging, University of California Davis)

  • David Kukis

    (Center for Molecular and Genomic Imaging, University of California Davis)

  • Chongxian Pan

    (University of California Davis
    VA Northern California Health Care System)

  • Kit S. Lam

    (UC Davis Comprehensive Cancer Center, University of California Davis
    University of California Davis)

Abstract

Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart ‘all-in-one’ nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.

Suggested Citation

  • Yuanpei Li & Tzu-yin Lin & Yan Luo & Qiangqiang Liu & Wenwu Xiao & Wenchang Guo & Diana Lac & Hongyong Zhang & Caihong Feng & Sebastian Wachsmann-Hogiu & Jeffrey H. Walton & Simon R. Cherry & Douglas , 2014. "A smart and versatile theranostic nanomedicine platform based on nanoporphyrin," Nature Communications, Nature, vol. 5(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5712
    DOI: 10.1038/ncomms5712
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    Cited by:

    1. Gang He & Yashi Li & Muhammad Rizwan Younis & Lian-Hua Fu & Ting He & Shan Lei & Jing Lin & Peng Huang, 2022. "Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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