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Licensing MLH1 sites for crossover during meiosis

Author

Listed:
  • Azahara C. Martín

    (John Innes Centre, Norwich Research Park)

  • Peter Shaw

    (John Innes Centre, Norwich Research Park)

  • Dylan Phillips

    (Institute of Biological, Environmental and Rural Sciences, Aberystwyth University)

  • Steve Reader

    (John Innes Centre, Norwich Research Park)

  • Graham Moore

    (John Innes Centre, Norwich Research Park)

Abstract

During meiosis, homologous chromosomes synapse and recombine at sites marked by the binding of the mismatch repair protein MLH1. In hexaploid wheat, the Ph1 locus has a major effect on whether crossover occurs between homologues or between related homoeologues. Here we report that—in wheat–rye hybrids where homologues are absent—Ph1 affects neither the level of synapsis nor the number of MLH1. Thus in the case of wheat–wild relative hybrids, Ph1 must affect whether MLH1 sites are able to progress to crossover. The observed level of synapsis implies that Ph1 functions to promote homologue pairing rather than suppress homoeologue pairing in wheat. Therefore, Ph1 stabilises polyploidy in wheat by both promoting homologue pairing and preventing MLH1 sites from becoming crossovers on paired homoeologues during meiosis.

Suggested Citation

  • Azahara C. Martín & Peter Shaw & Dylan Phillips & Steve Reader & Graham Moore, 2014. "Licensing MLH1 sites for crossover during meiosis," Nature Communications, Nature, vol. 5(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5580
    DOI: 10.1038/ncomms5580
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    Cited by:

    1. David Kopecký & Antonio Martín & Petr Smýkal, 2022. "Interspecific hybridization and plant breeding: From historical retrospective through work of Mendel to current crops," Czech Journal of Genetics and Plant Breeding, Czech Academy of Agricultural Sciences, vol. 58(3), pages 113-126.

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