Author
Listed:
- N. Lozovaya
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon
INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette
University Paris Descartes, CEA, Gif sur Yvette)
- S. Gataullina
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon
INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette
University Paris Descartes, CEA, Gif sur Yvette)
- T. Tsintsadze
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
- V. Tsintsadze
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
- E. Pallesi-Pocachard
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
- M. Minlebaev
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon
Laboratory of Neurobiology, Kazan Federal University)
- N. A. Goriounova
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
- E. Buhler
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
- F. Watrin
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
- S. Shityakov
(University of Würzburg)
- A. J. Becker
(University of Bonn Medical Center)
- A. Bordey
(Neurosurgery, Yale University School of Medicine)
- M. Milh
(APHM, CHU Timone)
- D. Scavarda
(APHM, CHU Timone)
- C. Bulteau
(INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette
University Paris Descartes, CEA, Gif sur Yvette
Foundation Rothschild)
- G. Dorfmuller
(INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette
University Paris Descartes, CEA, Gif sur Yvette
Foundation Rothschild)
- O. Delalande
(Foundation Rothschild)
- A. Represa
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
- C. Cardoso
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
- O. Dulac
(INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette
University Paris Descartes, CEA, Gif sur Yvette
Foundation Rothschild
APHP, Necker Hospital)
- Y. Ben-Ari
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
- N. Burnashev
(INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
UMR901, Aix-Marseille University, 58 Boulevard Charles Livon)
Abstract
Tuberous sclerosis complex (TSC), caused by dominant mutations in either TSC1 or TSC2 tumour suppressor genes is characterized by the presence of brain malformations, the cortical tubers that are thought to contribute to the generation of pharmacoresistant epilepsy. Here we report that tuberless heterozygote Tsc1+/− mice show functional upregulation of cortical GluN2C-containing N-methyl-D-aspartate receptors (NMDARs) in an mTOR-dependent manner and exhibit recurrent, unprovoked seizures during early postnatal life (
Suggested Citation
N. Lozovaya & S. Gataullina & T. Tsintsadze & V. Tsintsadze & E. Pallesi-Pocachard & M. Minlebaev & N. A. Goriounova & E. Buhler & F. Watrin & S. Shityakov & A. J. Becker & A. Bordey & M. Milh & D. Sc, 2014.
"Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model,"
Nature Communications, Nature, vol. 5(1), pages 1-15, December.
Handle:
RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5563
DOI: 10.1038/ncomms5563
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