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Latent homology and convergent regulatory evolution underlies the repeated emergence of yeasts

Author

Listed:
  • László G. Nagy

    (Clark University)

  • Robin A. Ohm

    (U.S. Department of Energy Joint Genome Institute)

  • Gábor M. Kovács

    (Institute of Biology, Eötvös Loránd University
    Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences)

  • Dimitrios Floudas

    (Clark University)

  • Robert Riley

    (U.S. Department of Energy Joint Genome Institute)

  • Attila Gácser

    (University of Szeged)

  • Mátyás Sipiczki

    (University of Debrecen)

  • John M. Davis

    (School of Forest Resources and Conservation, University of Florida)

  • Sharon L. Doty

    (School of Environmental and Forest Sciences, College of the Environment, University of Washington)

  • G Sybren de Hoog

    (CBS-KNAW Fungal Biodiversity Centre)

  • B. Franz Lang

    (Université de Montréal)

  • Joseph W. Spatafora

    (Oregon State University)

  • Francis M. Martin

    (INRA, UMR 1136, INRA-Nancy Université, Interactions Arbres/Microorganismes)

  • Igor V. Grigoriev

    (U.S. Department of Energy Joint Genome Institute)

  • David S. Hibbett

    (Clark University)

Abstract

Convergent evolution is common throughout the tree of life, but the molecular mechanisms causing similar phenotypes to appear repeatedly are obscure. Yeasts have arisen in multiple fungal clades, but the genetic causes and consequences of their evolutionary origins are unknown. Here we show that the potential to develop yeast forms arose early in fungal evolution and became dominant independently in multiple clades, most likely via parallel diversification of Zn-cluster transcription factors, a fungal-specific family involved in regulating yeast–filamentous switches. Our results imply that convergent evolution can happen by the repeated deployment of a conserved genetic toolkit for the same function in distinct clades via regulatory evolution. We suggest that this mechanism might be a common source of evolutionary convergence even at large time scales.

Suggested Citation

  • László G. Nagy & Robin A. Ohm & Gábor M. Kovács & Dimitrios Floudas & Robert Riley & Attila Gácser & Mátyás Sipiczki & John M. Davis & Sharon L. Doty & G Sybren de Hoog & B. Franz Lang & Joseph W. Spa, 2014. "Latent homology and convergent regulatory evolution underlies the repeated emergence of yeasts," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5471
    DOI: 10.1038/ncomms5471
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    Cited by:

    1. Balázs Bálint & Zsolt Merényi & Botond Hegedüs & Igor V. Grigoriev & Zhihao Hou & Csenge Földi & László G. Nagy, 2024. "ContScout: sensitive detection and removal of contamination from annotated genomes," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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