IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms5401.html
   My bibliography  Save this article

The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies

Author

Listed:
  • Stefania-Elisavet Kapsetaki

    (Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas)

  • Ilias Tzelepis

    (Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas)

  • Kalodoti Avgousti

    (University of Cyprus)

  • Ioannis Livadaras

    (Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas)

  • Nikos Garantonakis

    (Institute for Olive Tree & Subtropical Plants, National Agricultural Research Foundation, Agrokipio)

  • Kyriaki Varikou

    (Institute for Olive Tree & Subtropical Plants, National Agricultural Research Foundation, Agrokipio)

  • Yiorgos Apidianakis

    (Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas
    University of Cyprus)

Abstract

Bacteria contaminate insects and secrete metabolites that may affect insect behaviour and potentially fitness through unknown mechanisms. Here we show that the ‘grape-like’ odorant 2-aminoacetophenone (2AA), secreted by Pseudomonas aeruginosa (a ubiquitous opportunistic human pathogen), facilitates attraction to food for several fly species including Musca domestica, Ceratitis capitata and Drosophila melanogaster. Constant feeding on 2AA increases the level of long-term colonization of the flies’ intestine by P. aeruginosa. Odour perception is necessary for enhanced attraction to food containing 2AA, and expression in the Drosophila olfactory organs of odorant receptors Or49b and Or10a potentiates, while expression of Or85a inhibits, preference for 2AA. Our study shows that 2AA lures the flies to the bacterial source and increases the extent of colonization of the fly intestine by the bacteria that produce it, as a means to facilitate bacterial dissemination to new locations.

Suggested Citation

  • Stefania-Elisavet Kapsetaki & Ilias Tzelepis & Kalodoti Avgousti & Ioannis Livadaras & Nikos Garantonakis & Kyriaki Varikou & Yiorgos Apidianakis, 2014. "The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5401
    DOI: 10.1038/ncomms5401
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms5401
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms5401?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Aya Yanagawa & Claudine Neyen & Bruno Lemaitre & Frédéric Marion-Poll, 2017. "The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-15, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5401. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.