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The Opisthorchis viverrini genome provides insights into life in the bile duct

Author

Listed:
  • Neil D. Young

    (Faculty of Veterinary Science, The University of Melbourne, Melbourne)

  • Niranjan Nagarajan

    (Genome Institute of Singapore)

  • Suling Joyce Lin

    (Genome Institute of Singapore)

  • Pasi K. Korhonen

    (Faculty of Veterinary Science, The University of Melbourne, Melbourne)

  • Aaron R. Jex

    (Faculty of Veterinary Science, The University of Melbourne, Melbourne)

  • Ross S. Hall

    (Faculty of Veterinary Science, The University of Melbourne, Melbourne)

  • Helena Safavi-Hemami

    (University of Utah)

  • Worasak Kaewkong

    (Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University)

  • Denis Bertrand

    (Genome Institute of Singapore)

  • Song Gao

    (NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore)

  • Qihui Seet

    (Genome Institute of Singapore)

  • Sopit Wongkham

    (Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University)

  • Bin Tean Teh

    (Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School)

  • Chaisiri Wongkham

    (Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University)

  • Pewpan Maleewong Intapan

    (Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University)

  • Wanchai Maleewong

    (Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University)

  • Xinhua Yang
  • Min Hu
  • Zuo Wang
  • Andreas Hofmann

    (Faculty of Veterinary Science, The University of Melbourne, Melbourne
    Structural Chemistry Program, Eskitis Institute, Griffith University)

  • Paul W. Sternberg

    (HHMI, California Institute of Technology)

  • Patrick Tan

    (Genome Institute of Singapore
    Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School)

  • Jun Wang

    (University of Copenhagen
    Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University
    Macau University of Science and Technology, Avenida Wai long)

  • Robin B. Gasser

    (Faculty of Veterinary Science, The University of Melbourne, Melbourne)

Abstract

Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5 Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions.

Suggested Citation

  • Neil D. Young & Niranjan Nagarajan & Suling Joyce Lin & Pasi K. Korhonen & Aaron R. Jex & Ross S. Hall & Helena Safavi-Hemami & Worasak Kaewkong & Denis Bertrand & Song Gao & Qihui Seet & Sopit Wongkh, 2014. "The Opisthorchis viverrini genome provides insights into life in the bile duct," Nature Communications, Nature, vol. 5(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5378
    DOI: 10.1038/ncomms5378
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    Cited by:

    1. Neil D. Young & Andreas J. Stroehlein & Tao Wang & Pasi K. Korhonen & Margaret Mentink-Kane & J. Russell Stothard & David Rollinson & Robin B. Gasser, 2022. "Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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