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Sequencing-based approach identified three new susceptibility loci for psoriasis

Author

Listed:
  • Yujun Sheng

    (No. 2 Hospital, Anhui Medical University
    No. 1 Hospital, Anhui Medical University
    Huashan Hospital of Fudan University)

  • Xin Jin

    (BGI-Shenzhen
    School of Bioscience and Bioengineering, South China University of Technology)

  • Jinhua Xu

    (Huashan Hospital of Fudan University)

  • Jinping Gao

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Xiaoqing Du

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Dawei Duan

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Bing Li

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Jinhua Zhao

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Wenying Zhan

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Huayang Tang

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Xianfa Tang

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Yang Li

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Hui Cheng

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Xianbo Zuo

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Junpu Mei

    (BGI-Shenzhen)

  • Fusheng Zhou

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Bo Liang

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Gang Chen

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Changbing Shen

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Hongzhou Cui

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Xiaoguang Zhang

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Change Zhang

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Wenjun Wang

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Xiaodong Zheng

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Xing Fan

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Zaixing Wang

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Fengli Xiao

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Yong Cui

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Yingrui Li

    (BGI-Shenzhen)

  • Jun Wang

    (BGI-Shenzhen
    Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen
    University of Copenhagen)

  • Sen Yang

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Lei Xu

    (Rm1028 Ho Sin-Hang Engineering Building, The Chinese University of Hong Kong, Shatin, NT)

  • Liangdan Sun

    (No. 1 Hospital, Anhui Medical University
    Anhui Medical University
    Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China)

  • Xuejun Zhang

    (No. 2 Hospital, Anhui Medical University
    No. 1 Hospital, Anhui Medical University
    Huashan Hospital of Fudan University
    Anhui Medical University)

Abstract

In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10−20≤P≤2.41 × 10−7) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 10−8), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10−8) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10−8). Two suggestive loci, 3p21.31 and 17q25, are also identified with P

Suggested Citation

  • Yujun Sheng & Xin Jin & Jinhua Xu & Jinping Gao & Xiaoqing Du & Dawei Duan & Bing Li & Jinhua Zhao & Wenying Zhan & Huayang Tang & Xianfa Tang & Yang Li & Hui Cheng & Xianbo Zuo & Junpu Mei & Fusheng , 2014. "Sequencing-based approach identified three new susceptibility loci for psoriasis," Nature Communications, Nature, vol. 5(1), pages 1-6, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5331
    DOI: 10.1038/ncomms5331
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    Cited by:

    1. Ruolin Li & Wenjin Luo & Xiangjun Chen & Qinglian Zeng & Shumin Yang & Ping Wang & Jinbo Hu & Aijun Chen, 2024. "An observational and genetic investigation into the association between psoriasis and risk of malignancy," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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