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Engineering interlocking DNA rings with weak physical interactions

Author

Listed:
  • Zai-Sheng Wu

    (Michael G. DeGroote Institute of Infectious Disease Research, McMaster University
    Department of Chemistry and Chemical Biology
    Cancer Metastasis Alert and Prevention Center, College of Chemistry and Chemical Engineering, Fuzhou University)

  • Zhifa Shen

    (Michael G. DeGroote Institute of Infectious Disease Research, McMaster University
    Department of Chemistry and Chemical Biology)

  • Kha Tram

    (Michael G. DeGroote Institute of Infectious Disease Research, McMaster University
    Department of Chemistry and Chemical Biology)

  • Yingfu Li

    (Michael G. DeGroote Institute of Infectious Disease Research, McMaster University
    Department of Chemistry and Chemical Biology)

Abstract

Catenanes are intriguing molecular assemblies for engineering unique molecular devices. The resident rings of a catenane are expected to execute unhindered rotation around each other, and to do so, they must have weak physical interactions with each other. Due to sequence programmability, DNA has become a popular material for nanoscale object engineering. However, current DNA catenanes, particularly in the single-stranded (ss) form, are synthesized through the formation of a linking duplex, which makes them less ideal as mobile elements for molecular machines. Herein we adopt a random library approach to engineer ssDNA [2] catenanes (two interlocked DNA rings) without a linking duplex. Results from DNA hybridization, double-stranded catenane synthesis and rolling circle amplification experiments signify that representative catenanes have weak physical interactions and are capable of operating as independent units. Our findings lay the foundation for exploring free-functioning interlocked DNA rings for the design of elaborate nanoscale machines based on DNA.

Suggested Citation

  • Zai-Sheng Wu & Zhifa Shen & Kha Tram & Yingfu Li, 2014. "Engineering interlocking DNA rings with weak physical interactions," Nature Communications, Nature, vol. 5(1), pages 1-10, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5279
    DOI: 10.1038/ncomms5279
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    Cited by:

    1. Danyu Wang & Jingwen Liu & Jie Duan & Hua Yi & Junjie Liu & Haiwei Song & Zhenzhong Zhang & Jinjin Shi & Kaixiang Zhang, 2023. "Enrichment and sensing tumor cells by embedded immunomodulatory DNA hydrogel to inhibit postoperative tumor recurrence," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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