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Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication

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  • Umut Sahin

    (Université Paris Diderot, Sorbonne Paris Cité, Hôpital St Louis
    INSERM U944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie, Hôpital St Louis
    CNRS UMR 7212, Hôpital St Louis)

  • Omar Ferhi

    (Université Paris Diderot, Sorbonne Paris Cité, Hôpital St Louis
    INSERM U944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie, Hôpital St Louis
    CNRS UMR 7212, Hôpital St Louis)

  • Xavier Carnec

    (Université Paris Diderot, Sorbonne Paris Cité, Hôpital St Louis
    INSERM U944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie, Hôpital St Louis
    CNRS UMR 7212, Hôpital St Louis)

  • Alessia Zamborlini

    (Université Paris Diderot, Sorbonne Paris Cité, Hôpital St Louis
    INSERM U944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie, Hôpital St Louis
    CNRS UMR 7212, Hôpital St Louis
    Conservatoire National des Arts et Métiers)

  • Laurent Peres

    (Université Paris Diderot, Sorbonne Paris Cité, Hôpital St Louis
    INSERM U944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie, Hôpital St Louis
    CNRS UMR 7212, Hôpital St Louis)

  • Florence Jollivet

    (Université Paris Diderot, Sorbonne Paris Cité, Hôpital St Louis
    INSERM U944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie, Hôpital St Louis
    CNRS UMR 7212, Hôpital St Louis)

  • Adeline Vitaliano-Prunier

    (Université Paris Diderot, Sorbonne Paris Cité, Hôpital St Louis
    INSERM U944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie, Hôpital St Louis
    CNRS UMR 7212, Hôpital St Louis)

  • Hugues de Thé

    (Université Paris Diderot, Sorbonne Paris Cité, Hôpital St Louis
    INSERM U944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie, Hôpital St Louis
    CNRS UMR 7212, Hôpital St Louis)

  • Valérie Lallemand-Breitenbach

    (Université Paris Diderot, Sorbonne Paris Cité, Hôpital St Louis
    INSERM U944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d’Hématologie, Hôpital St Louis
    CNRS UMR 7212, Hôpital St Louis)

Abstract

Small ubiquitin-related modifier (SUMO) protein conjugation onto target proteins regulates multiple cellular functions, including defence against pathogens, stemness and senescence. SUMO1 peptides are limiting in quantity and are thus mainly conjugated to high-affinity targets. Conjugation of SUMO2/3 paralogues is primarily stress inducible and may initiate target degradation. Here we demonstrate that the expression of SUMO1/2/3 is dramatically enhanced by interferons through an miRNA-based mechanism involving the Lin28/let-7 axis, a master regulator of stemness. Normal haematopoietic progenitors indeed display much higher SUMO contents than their differentiated progeny. Critically, SUMOs contribute to the antiviral effects of interferons against HSV1 or HIV. Promyelocytic leukemia (PML) nuclear bodies are interferon-induced domains, which facilitate sumoylation of a subset of targets. Our findings thus identify an integrated interferon-responsive PML/SUMO pathway that impedes viral replication by enhancing SUMO conjugation and possibly also modifying the repertoire of targets. Interferon-enhanced post-translational modifications may be essential for senescence or stem cell self-renewal, and initiate SUMO-dependent proteolysis.

Suggested Citation

  • Umut Sahin & Omar Ferhi & Xavier Carnec & Alessia Zamborlini & Laurent Peres & Florence Jollivet & Adeline Vitaliano-Prunier & Hugues de Thé & Valérie Lallemand-Breitenbach, 2014. "Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication," Nature Communications, Nature, vol. 5(1), pages 1-8, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5187
    DOI: 10.1038/ncomms5187
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    Cited by:

    1. Sarah Tessier & Omar Ferhi & Marie-Claude Geoffroy & Román González-Prieto & Antoine Canat & Samuel Quentin & Marika Pla & Michiko Niwa-Kawakita & Pierre Bercier & Domitille Rérolle & Marilyn Tirard &, 2022. "Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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