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Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes

Author

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  • Konstantin A. Tsetsarkin

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

  • Rubing Chen

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

  • Ruimei Yun

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

  • Shannan L. Rossi

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

  • Kenneth S. Plante

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

  • Mathilde Guerbois

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

  • Naomi Forrester

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

  • Guey Chuen Perng

    (Emory Vaccine Center, Emory University School of Medicine
    College of Medicine, National Cheng Kung University
    Center of Infectious Disease and Signaling Research, National Cheng Kung University)

  • Easwaran Sreekumar

    (Viral Disease Biology Program, Rajiv Gandhi Centre for Biotechnology (RGCB))

  • Grace Leal

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

  • Jing Huang

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

  • Suchetana Mukhopadhyay

    (Indiana University)

  • Scott C. Weaver

    (Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch)

Abstract

Host species-specific fitness landscapes largely determine the outcome of host switching during pathogen emergence. Using chikungunya virus (CHIKV) to study adaptation to a mosquito vector, we evaluated mutations associated with recently evolved sub-lineages. Multiple Aedes albopictus-adaptive fitness peaks became available after CHIKV acquired an initial adaptive (E1-A226V) substitution, permitting rapid lineage diversification observed in nature. All second-step mutations involved replacements by glutamine or glutamic acid of E2 glycoprotein amino acids in the acid-sensitive region, providing a framework to anticipate additional A. albopictus-adaptive mutations. The combination of second-step adaptive mutations into a single, ‘super-adaptive’ fitness peak also predicted the future emergence of CHIKV strains with even greater transmission efficiency in some current regions of endemic circulation, followed by their likely global spread.

Suggested Citation

  • Konstantin A. Tsetsarkin & Rubing Chen & Ruimei Yun & Shannan L. Rossi & Kenneth S. Plante & Mathilde Guerbois & Naomi Forrester & Guey Chuen Perng & Easwaran Sreekumar & Grace Leal & Jing Huang & Suc, 2014. "Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes," Nature Communications, Nature, vol. 5(1), pages 1-14, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5084
    DOI: 10.1038/ncomms5084
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    Cited by:

    1. Joilson Xavier & Luiz Carlos Junior Alcantara & Vagner Fonseca & Mauricio Lima & Emerson Castro & Hegger Fritsch & Carla Oliveira & Natalia Guimarães & Talita Adelino & Mariane Evaristo & Evandra S. R, 2023. "Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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