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A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains

Author

Listed:
  • Mark D. Preston

    (London School of Hygiene and Tropical Medicine)

  • Susana Campino

    (Malaria Programme, Wellcome Trust Sanger Institute)

  • Samuel A. Assefa

    (London School of Hygiene and Tropical Medicine)

  • Diego F. Echeverry

    (Purdue University
    International Center for Medical Research and Training)

  • Harold Ocholla

    (College of Medicine, University of Malawi
    Malawi-Liverpool-Wellcome Trust Clinical Research Programme
    Malaria Capacity Development Consortium, Liverpool School of Tropical Medicine)

  • Alfred Amambua-Ngwa

    (Medical Research Council Laboratories (UK))

  • Lindsay B. Stewart

    (London School of Hygiene and Tropical Medicine)

  • David J. Conway

    (London School of Hygiene and Tropical Medicine
    Medical Research Council Laboratories (UK))

  • Steffen Borrmann

    (KEMRI-Wellcome Trust Research Programme
    Institute of Tropical Medicine, University of Tübingen)

  • Pascal Michon

    (Faculty of Health Sciences, Divine Word University)

  • Issaka Zongo

    (Institut de Recherche en Sciences de la Sant)

  • Jean-Bosco Ouédraogo

    (Institut de Recherche en Sciences de la Sant)

  • Abdoulaye A. Djimde

    (Malaria Programme, Wellcome Trust Sanger Institute
    Malaria Research and Training Centre, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako)

  • Ogobara K. Doumbo

    (Malaria Research and Training Centre, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako)

  • Francois Nosten

    (Centre for Tropical Medicine, University of Oxford
    Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University)

  • Arnab Pain

    (Pathogen Genomics Laboratory, King Abdullah University of Science and Technology)

  • Teun Bousema

    (London School of Hygiene and Tropical Medicine)

  • Chris J. Drakeley

    (London School of Hygiene and Tropical Medicine)

  • Rick M. Fairhurst

    (Malaria Pathogenesis and Human Immunity Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Colin J. Sutherland

    (London School of Hygiene and Tropical Medicine)

  • Cally Roper

    (London School of Hygiene and Tropical Medicine)

  • Taane G. Clark

    (London School of Hygiene and Tropical Medicine)

Abstract

Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (~92%) and easily adapted to aid case management in the field and survey parasite migration worldwide.

Suggested Citation

  • Mark D. Preston & Susana Campino & Samuel A. Assefa & Diego F. Echeverry & Harold Ocholla & Alfred Amambua-Ngwa & Lindsay B. Stewart & David J. Conway & Steffen Borrmann & Pascal Michon & Issaka Zongo, 2014. "A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains," Nature Communications, Nature, vol. 5(1), pages 1-7, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5052
    DOI: 10.1038/ncomms5052
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    Cited by:

    1. Ernest Diez Benavente & Monica Campos & Jody Phelan & Debbie Nolder & Jamille G Dombrowski & Claudio R F Marinho & Kanlaya Sriprawat & Aimee R Taylor & James Watson & Cally Roper & Francois Nosten & C, 2020. "A molecular barcode to inform the geographical origin and transmission dynamics of Plasmodium vivax malaria," PLOS Genetics, Public Library of Science, vol. 16(2), pages 1-19, February.

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