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Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

Author

Listed:
  • Falguni Pati

    (Pohang University of Science and Technology (POSTECH))

  • Jinah Jang

    (Pohang University of Science and Technology (POSTECH)
    University of Washington)

  • Dong-Heon Ha

    (Pohang University of Science and Technology (POSTECH))

  • Sung Won Kim

    (College of Medicine, The Catholic University of Korea
    College of Medicine, The Catholic University of Korea)

  • Jong-Won Rhie

    (College of Medicine, The Catholic University of Korea)

  • Jin-Hyung Shim

    (Korea Polytechnic University)

  • Deok-Ho Kim

    (University of Washington
    Center for Cardiovascular Biology, University of Washington
    Institute for Stem Cell and Regenerative Medicine, University of Washington)

  • Dong-Woo Cho

    (Pohang University of Science and Technology (POSTECH))

Abstract

The ability to print and pattern all the components that make up a tissue (cells and matrix materials) in three dimensions to generate structures similar to tissues is an exciting prospect of bioprinting. However, the majority of the matrix materials used so far for bioprinting cannot represent the complexity of natural extracellular matrix (ECM) and thus are unable to reconstitute the intrinsic cellular morphologies and functions. Here, we develop a method for the bioprinting of cell-laden constructs with novel decellularized extracellular matrix (dECM) bioink capable of providing an optimized microenvironment conducive to the growth of three-dimensional structured tissue. We show the versatility and flexibility of the developed bioprinting process using tissue-specific dECM bioinks, including adipose, cartilage and heart tissues, capable of providing crucial cues for cells engraftment, survival and long-term function. We achieve high cell viability and functionality of the printed dECM structures using our bioprinting method.

Suggested Citation

  • Falguni Pati & Jinah Jang & Dong-Heon Ha & Sung Won Kim & Jong-Won Rhie & Jin-Hyung Shim & Deok-Ho Kim & Dong-Woo Cho, 2014. "Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink," Nature Communications, Nature, vol. 5(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4935
    DOI: 10.1038/ncomms4935
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    Cited by:

    1. Suran Kim & Sungjin Min & Yi Sun Choi & Sung-Hyun Jo & Jae Hun Jung & Kyusun Han & Jin Kim & Soohwan An & Yong Woo Ji & Yun-Gon Kim & Seung-Woo Cho, 2022. "Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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