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Construction of RNA nanocages by re-engineering the packaging RNA of Phi29 bacteriophage

Author

Listed:
  • Chenhui Hao

    (Purdue University)

  • Xiang Li

    (Purdue University)

  • Cheng Tian

    (Purdue University)

  • Wen Jiang

    (Markey Center for Structural Biology, Purdue University)

  • Guansong Wang

    (The Institute of Respiratory Diseases, Xinqiao Hospital)

  • Chengde Mao

    (Purdue University)

Abstract

RNA nanotechnology promises rational design of RNA nanostructures with wide array of structural diversities and functionalities. Such nanostructures could be used in applications such as small interfering RNA delivery and organization of in vivo chemical reactions. Though having impressive development in recent years, RNA nanotechnology is still quite limited and its programmability and complexity could not rival the degree of its closely related cousin: DNA nanotechnology. Novel strategies are needed for programmed RNA self-assembly. Here, we have assembled RNA nanocages by re-engineering a natural, biological RNA motif: the packaging RNA of phi29 bacteriophage. The resulting RNA nanostructures have been thoroughly characterized by gel electrophoresis, cryogenic electron microscopy imaging and dynamic light scattering.

Suggested Citation

  • Chenhui Hao & Xiang Li & Cheng Tian & Wen Jiang & Guansong Wang & Chengde Mao, 2014. "Construction of RNA nanocages by re-engineering the packaging RNA of Phi29 bacteriophage," Nature Communications, Nature, vol. 5(1), pages 1-7, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4890
    DOI: 10.1038/ncomms4890
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    Cited by:

    1. Peter Eastman & Jade Shi & Bharath Ramsundar & Vijay S Pande, 2018. "Solving the RNA design problem with reinforcement learning," PLOS Computational Biology, Public Library of Science, vol. 14(6), pages 1-15, June.

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