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Magnetophoretic circuits for digital control of single particles and cells

Author

Listed:
  • Byeonghwa Lim

    (Daegu Gyeongbuk Institute of Science and Technology (DGIST)
    School of Engineering, Chungnam National University)

  • Venu Reddy

    (Daegu Gyeongbuk Institute of Science and Technology (DGIST)
    School of Engineering, Chungnam National University)

  • XingHao Hu

    (Daegu Gyeongbuk Institute of Science and Technology (DGIST)
    School of Engineering, Chungnam National University)

  • KunWoo Kim

    (Daegu Gyeongbuk Institute of Science and Technology (DGIST)
    School of Engineering, Chungnam National University)

  • Mital Jadhav

    (School of Engineering, Chungnam National University)

  • Roozbeh Abedini-Nassab

    (Duke University
    University of Michigan–Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University)

  • Young-Woock Noh

    (School of Engineering, Chungnam National University)

  • Yong Taik Lim

    (SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University)

  • Benjamin B. Yellen

    (Duke University
    University of Michigan–Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University)

  • CheolGi Kim

    (Daegu Gyeongbuk Institute of Science and Technology (DGIST)
    School of Engineering, Chungnam National University)

Abstract

The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.

Suggested Citation

  • Byeonghwa Lim & Venu Reddy & XingHao Hu & KunWoo Kim & Mital Jadhav & Roozbeh Abedini-Nassab & Young-Woock Noh & Yong Taik Lim & Benjamin B. Yellen & CheolGi Kim, 2014. "Magnetophoretic circuits for digital control of single particles and cells," Nature Communications, Nature, vol. 5(1), pages 1-10, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4846
    DOI: 10.1038/ncomms4846
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    Cited by:

    1. Nico C. X. Stuhlmüller & Farzaneh Farrokhzad & Piotr Kuświk & Feliks Stobiecki & Maciej Urbaniak & Sapida Akhundzada & Arno Ehresmann & Thomas M. Fischer & Daniel de las Heras, 2023. "Simultaneous and independent topological control of identical microparticles in non-periodic energy landscapes," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Zhiyuan Zhang & Alexander Sukhov & Jens Harting & Paolo Malgaretti & Daniel Ahmed, 2022. "Rolling microswarms along acoustic virtual walls," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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