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S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

Author

Listed:
  • Jyoti K. Jaiswal

    (Children’s National Medical Center, Center for Genetic Medicine Research)

  • Stine P. Lauritzen

    (Unit for Cell Death and Metabolism, Danish Cancer Society Research Center)

  • Luana Scheffer

    (Children’s National Medical Center, Center for Genetic Medicine Research)

  • Masakiyo Sakaguchi

    (Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kitaku)

  • Jakob Bunkenborg

    (Copenhagen University Hospital Hvidovre)

  • Sanford M. Simon

    (Laboratory of Cellular Biophysics, The Rockefeller University)

  • Tuula Kallunki

    (Unit for Cell Death and Metabolism, Danish Cancer Society Research Center)

  • Marja Jäättelä

    (Unit for Cell Death and Metabolism, Danish Cancer Society Research Center)

  • Jesper Nylandsted

    (Unit for Cell Death and Metabolism, Danish Cancer Society Research Center)

Abstract

Cell migration and invasion require increased plasma membrane dynamics and ability to navigate through dense stroma, thereby exposing plasma membrane to tremendous physical stress. Yet, it is largely unknown how metastatic cancer cells acquire an ability to cope with such stress. Here we show that S100A11, a calcium-binding protein upregulated in a variety of metastatic cancers, is essential for efficient plasma membrane repair and survival of highly motile cancer cells. Plasma membrane injury-induced entry of calcium into the cell triggers recruitment of S100A11 and Annexin A2 to the site of injury. We show that S100A11 in a complex with Annexin A2 helps reseal the plasma membrane by facilitating polymerization of cortical F-actin and excision of the damaged part of the plasma membrane. These data reveal plasma membrane repair in general and S100A11 and Annexin A2 in particular as new targets for the therapy of metastatic cancers.

Suggested Citation

  • Jyoti K. Jaiswal & Stine P. Lauritzen & Luana Scheffer & Masakiyo Sakaguchi & Jakob Bunkenborg & Sanford M. Simon & Tuula Kallunki & Marja Jäättelä & Jesper Nylandsted, 2014. "S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells," Nature Communications, Nature, vol. 5(1), pages 1-13, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4795
    DOI: 10.1038/ncomms4795
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    1. Roger Moreno-Justicia & Thibaux Van der Stede & Ben Stocks & Jenni Laitila & Robert A. Seaborne & Alexia Van de Loock & Eline Lievens & Diana Samodova & Leyre Marín-Arraiza & Oksana Dmytriyeva & Robin, 2025. "Human skeletal muscle fiber heterogeneity beyond myosin heavy chains," Nature Communications, Nature, vol. 16(1), pages 1-18, December.

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