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Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure

Author

Listed:
  • Olga Ossipova

    (Icahn School of Medicine at Mount Sinai)

  • Kyeongmi Kim

    (Icahn School of Medicine at Mount Sinai)

  • Blue B. Lake

    (Icahn School of Medicine at Mount Sinai)

  • Keiji Itoh

    (Icahn School of Medicine at Mount Sinai)

  • Andriani Ioannou

    (Icahn School of Medicine at Mount Sinai)

  • Sergei Y. Sokol

    (Icahn School of Medicine at Mount Sinai)

Abstract

Epithelial folding is a critical process underlying many morphogenetic events including vertebrate neural tube closure, however, its spatial regulation is largely unknown. Here we show that during neural tube formation Rab11-positive recycling endosomes acquire bilaterally symmetric distribution in the Xenopus neural plate, being enriched at medial apical cell junctions. This mediolateral polarization was under the control of planar cell polarity (PCP) signalling, was necessary for neural plate folding and was accompanied by the polarization of the exocyst component Sec15. Our further experiments demonstrate that similar PCP-dependent polarization of Rab11 is essential for ectopic apical constriction driven by the actin-binding protein Shroom and during embryonic wound repair. We propose that anisotropic membrane trafficking has key roles in diverse morphogenetic behaviours of individual cells and propagates in a tissue by a common mechanism that involves PCP.

Suggested Citation

  • Olga Ossipova & Kyeongmi Kim & Blue B. Lake & Keiji Itoh & Andriani Ioannou & Sergei Y. Sokol, 2014. "Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure," Nature Communications, Nature, vol. 5(1), pages 1-8, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4734
    DOI: 10.1038/ncomms4734
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    Cited by:

    1. Miho Matsuda & Jan Rozman & Sassan Ostvar & Karen E. Kasza & Sergei Y. Sokol, 2023. "Mechanical control of neural plate folding by apical domain alteration," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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