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Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

Author

Listed:
  • Peter S. Lee

    (The Scripps Research Institute
    The Skaggs Institute of Chemical Biology, The Scripps Research Institute)

  • Nobuko Ohshima

    (Institute for Comprehensive Medical Science, Fujita Health University)

  • Robyn L. Stanfield

    (The Scripps Research Institute)

  • Wenli Yu

    (The Scripps Research Institute)

  • Yoshitaka Iba

    (Institute for Comprehensive Medical Science, Fujita Health University)

  • Yoshinobu Okuno

    (Kanonji Institute, The Research Foundation for Microbial Diseases, Osaka University)

  • Yoshikazu Kurosawa

    (Institute for Comprehensive Medical Science, Fujita Health University)

  • Ian A. Wilson

    (The Scripps Research Institute
    The Skaggs Institute of Chemical Biology, The Scripps Research Institute)

Abstract

Influenza viruses present a significant health challenge each year, as in the H3N2 epidemic of 2012–2013. Here we describe an antibody, F045–092, that possesses broadly neutralizing activity against the entire H3 subtype and accommodates the natural variation and additional glycosylation in all strains tested from 1963 to 2011. Crystal structures of F045–092 in complex with HAs from 1975 and 2011 H3N2 viruses reveal the structural basis for its neutralization breadth through insertion of its 23-residue HCDR3 into the receptor-binding site that involves striking receptor mimicry. F045–092 extends its recognition to divergent subtypes, including H1, H2 and H13, using the enhanced avidity of its IgG to overcome lower-affinity Fab binding, as observed with other antibodies that target the receptor-binding site. This unprecedented level of antibody cross-reactivity against the H3 subtype can potentially inform on development of a pan-H3 vaccine or small-molecule therapeutics.

Suggested Citation

  • Peter S. Lee & Nobuko Ohshima & Robyn L. Stanfield & Wenli Yu & Yoshitaka Iba & Yoshinobu Okuno & Yoshikazu Kurosawa & Ian A. Wilson, 2014. "Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus," Nature Communications, Nature, vol. 5(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4614
    DOI: 10.1038/ncomms4614
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    Cited by:

    1. Ruipeng Lei & Weiwen Liang & Wenhao O. Ouyang & Andrea Hernandez Garcia & Chika Kikuchi & Shengyang Wang & Ryan McBride & Timothy J. C. Tan & Yuanxin Sun & Chunke Chen & Claire S. Graham & Lucia A. Ro, 2024. "Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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