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Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

Author

Listed:
  • Byung Cheon Lee

    (Brigham & Women’s Hospital and Harvard Medical School)

  • Alaattin Kaya

    (Brigham & Women’s Hospital and Harvard Medical School)

  • Siming Ma

    (Brigham & Women’s Hospital and Harvard Medical School)

  • Gwansu Kim

    (Korea University)

  • Maxim V. Gerashchenko

    (Brigham & Women’s Hospital and Harvard Medical School)

  • Sun Hee Yim

    (Brigham & Women’s Hospital and Harvard Medical School)

  • Zhen Hu

    (School of Biological Sciences, University of Nebraska-Lincoln)

  • Lawrence G. Harshman

    (School of Biological Sciences, University of Nebraska-Lincoln)

  • Vadim N. Gladyshev

    (Brigham & Women’s Hospital and Harvard Medical School)

Abstract

Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino-acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino-acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signalling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino-acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.

Suggested Citation

  • Byung Cheon Lee & Alaattin Kaya & Siming Ma & Gwansu Kim & Maxim V. Gerashchenko & Sun Hee Yim & Zhen Hu & Lawrence G. Harshman & Vadim N. Gladyshev, 2014. "Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status," Nature Communications, Nature, vol. 5(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4592
    DOI: 10.1038/ncomms4592
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    Cited by:

    1. Hyo Sub Choi & Ajay Bhat & Marshall B. Howington & Megan L. Schaller & Rebecca L. Cox & Shijiao Huang & Safa Beydoun & Hillary A. Miller & Angela M. Tuckowski & Joy Mecano & Elizabeth S. Dean & Lindy , 2023. "FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Grace Y. Liu & Patrick Jouandin & Raymond E. Bahng & Norbert Perrimon & David M. Sabatini, 2024. "An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Hina Kosakamoto & Fumiaki Obata & Junpei Kuraishi & Hide Aikawa & Rina Okada & Joshua N. Johnstone & Taro Onuma & Matthew D. W. Piper & Masayuki Miura, 2023. "Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Ruohong Wang & Yandong Yin & Jingshu Li & Hongmiao Wang & Wanting Lv & Yang Gao & Tangci Wang & Yedan Zhong & Zhiwei Zhou & Yuping Cai & Xiaoyang Su & Nan Liu & Zheng-Jiang Zhu, 2022. "Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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