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Plant GSK3 proteins regulate xylem cell differentiation downstream of TDIF–TDR signalling

Author

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  • Yuki Kondo

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Tasuku Ito

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411-8540, Japan)

  • Hirofumi Nakagami

    (RIKEN Center for Sustainable Resource Science, 7-22 Suehiro-cho, Tsurumi-ku, Kanagawa, Yokohama, Japan)

  • Yuki Hirakawa

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    School of Biological Sciences, Monash University)

  • Masato Saito

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Takayuki Tamaki

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Ken Shirasu

    (RIKEN Center for Sustainable Resource Science, 7-22 Suehiro-cho, Tsurumi-ku, Kanagawa, Yokohama, Japan)

  • Hiroo Fukuda

    (Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

Abstract

During plant radial growth typically seen in trees, procambial and cambial cells act as meristematic cells in the vascular system to self-proliferate and differentiate into xylem cells. These two processes are regulated by a signalling pathway composed of a peptide ligand and its receptor; tracheary element differentiation inhibitory factor (TDIF) and TDIF RECEPTOR (TDR). Here we show that glycogen synthase kinase 3 proteins (GSK3s) are crucial downstream components of the TDIF signalling pathway suppressing xylem differentiation from procambial cells. TDR interacts with GSK3s at the plasma membrane and activates GSK3s in a TDIF-dependent fashion. Consistently, a specific inhibitor of plant GSK3s strongly induces xylem cell differentiation through BRI1-EMS SUPPRESSOR 1 (BES1), a well-known target transcription factor of GSK3s. Our findings provide insight into the regulation of cell fate determination in meristem maintenance.

Suggested Citation

  • Yuki Kondo & Tasuku Ito & Hirofumi Nakagami & Yuki Hirakawa & Masato Saito & Takayuki Tamaki & Ken Shirasu & Hiroo Fukuda, 2014. "Plant GSK3 proteins regulate xylem cell differentiation downstream of TDIF–TDR signalling," Nature Communications, Nature, vol. 5(1), pages 1-11, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4504
    DOI: 10.1038/ncomms4504
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    1. Ryo Tachibana & Susumu Abe & Momo Marugami & Ayumi Yamagami & Rino Akema & Takao Ohashi & Kaisei Nishida & Shohei Nosaki & Takuya Miyakawa & Masaru Tanokura & Jong-Myong Kim & Motoaki Seki & Takehito , 2024. "BPG4 regulates chloroplast development and homeostasis by suppressing GLK transcription factors and involving light and brassinosteroid signaling," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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