IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms4448.html
   My bibliography  Save this article

DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering

Author

Listed:
  • Vivek V. Thacker

    (Cavendish Laboratory, JJ Thompson Avenue)

  • Lars O. Herrmann

    (Cavendish Laboratory, JJ Thompson Avenue)

  • Daniel O. Sigle

    (Cavendish Laboratory, JJ Thompson Avenue)

  • Tao Zhang

    (Ludwig-Maximilians-Universität München, Geschwister-Scholl-Platz 1)

  • Tim Liedl

    (Ludwig-Maximilians-Universität München, Geschwister-Scholl-Platz 1)

  • Jeremy J. Baumberg

    (Cavendish Laboratory, JJ Thompson Avenue)

  • Ulrich F. Keyser

    (Cavendish Laboratory, JJ Thompson Avenue)

Abstract

Plasmonic sensors are extremely promising candidates for label-free single-molecule analysis but require exquisite control over the physical arrangement of metallic nanostructures. Here we employ self-assembly based on the DNA origami technique for accurate positioning of individual gold nanoparticles. Our innovative design leads to strong plasmonic coupling between two 40 nm gold nanoparticles reproducibly held with gaps of 3.3±1 nm. This is confirmed through far field scattering measurements on individual dimers which reveal a significant red shift in the plasmonic resonance peaks, consistent with the high dielectric environment due to the surrounding DNA. We use surface-enhanced Raman scattering (SERS) to demonstrate local field enhancements of several orders of magnitude through detection of a small number of dye molecules as well as short single-stranded DNA oligonucleotides. This demonstrates that DNA origami is a powerful tool for the high-yield creation of SERS-active nanoparticle assemblies with reliable sub-5 nm gap sizes.

Suggested Citation

  • Vivek V. Thacker & Lars O. Herrmann & Daniel O. Sigle & Tao Zhang & Tim Liedl & Jeremy J. Baumberg & Ulrich F. Keyser, 2014. "DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering," Nature Communications, Nature, vol. 5(1), pages 1-7, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4448
    DOI: 10.1038/ncomms4448
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms4448
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms4448?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Francis Schuknecht & Karol Kołątaj & Michael Steinberger & Tim Liedl & Theobald Lohmueller, 2023. "Accessible hotspots for single-protein SERS in DNA-origami assembled gold nanorod dimers with tip-to-tip alignment," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Swarup Dey & Adam Dorey & Leeza Abraham & Yongzheng Xing & Irene Zhang & Fei Zhang & Stefan Howorka & Hao Yan, 2022. "A reversibly gated protein-transporting membrane channel made of DNA," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4448. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.